Am J Perinatol 2017; 34(01): 70-73
DOI: 10.1055/s-0036-1584275
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The Association between the Intertwin Interval and Adverse Neonatal Outcomes

Kate Swanson
1  Department of Obstetrics and Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois
,
William A. Grobman
1  Department of Obstetrics and Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois
2  Division of Maternal Fetal Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois
,
Emily S. Miller
1  Department of Obstetrics and Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois
2  Division of Maternal Fetal Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois
› Author Affiliations
Further Information

Publication History

09 March 2016

27 April 2016

Publication Date:
30 May 2016 (online)

Abstract

Objective Previous data examining the association between the interval between the delivery of the first and second twin (intertwin interval) and adverse neonatal outcomes are conflicting. We sought to evaluate whether intertwin interval is associated with adverse neonatal outcomes for the second twin in a contemporary U. S. cohort.

Methods This is a cohort study of women who delivered twins at or after 32 weeks gestation between 2006 and 2014 and whose first twin was delivered vaginally vertex. The intertwin interval was dichotomized as < 10 minutes or ≥ 10 minutes. Adverse outcomes included arterial cord pH ≤ 7.1, admission to the neonatal intensive care unit, respiratory distress, intraventricular hemorrhage, and death.

Results Of the 171 subjects, 61 (35.7%) had an intertwin interval of ≥ 10 minutes. There were no differences in maternal characteristics. Intertwin interval of ≥ 10 minutes was associated with an increased frequency of arterial pH ≤ 7.1 (22.0 vs. 8.2%, p = 0.03), which persisted after adjusting for confounders (adjusted odds ratio, 2.94; 95% confidence interval, 1.04–8.33). Other adverse outcomes did not differ.

Conclusion Intertwin interval of ≥ 10 minutes was associated with increased frequency of arterial pH ≤ 7.1 in the second twin, but no other adverse neonatal outcomes.