Highly Efficient Construction of Sugar-Fused Spirochromanono Pyrrolidines/Pyrrolizidines/Thiolizidines via 1,3-Dipolar Cycloaddition of Azomethine YlidesWe thank the Council of Scientific and Industrial Research, New Delhi, India (Award Letter No: 09/115(0733)/2011-EMR-I) for financial support.
Received: 29 May 2017
Accepted after revision: 11 July 2017
01 August 2017 (online)
A variety of sugar-fused chromanono pyrrolidines/pyrrolizidines/thiolizidines have been synthesized by intermolecular 1,3-dipolar cycloaddition reaction of azomethine ylides (generated from glucose aldehyde and different secondary amino acids) with various 3-arylidene chroman-4-ones as dipolarophiles. The solvent effect on the 1,3-dipolar cycloaddition reaction is also studied.