CC BY ND NC 4.0 · SynOpen 2017; 01(01): 0063-0067
DOI: 10.1055/s-0036-1588520
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Highly Efficient Construction of Sugar-Fused Spirochromanono Pyrrolidines/Pyrrolizidines/Thiolizidines via 1,3-Dipolar Cycloaddition of Azomethine Ylides

Sirisha Nallamalaa, Srikumar Mannem*b, Raghunathan Raghavachary*a
We thank the Council of Scientific and Industrial Research, New Delhi, India (Award Letter No: 09/115(0733)/2011-EMR-I) for financial support.
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Publication History

Received: 29 May 2017

Accepted after revision: 11 July 2017

Publication Date:
01 August 2017 (online)

Abstract

A variety of sugar-fused chromanono pyrrolidines/pyrrolizidines/thiolizidines have been synthesized by intermolecular 1,3-dipolar cycloaddition reaction of azomethine ylides (generated from glucose aldehyde and different secondary amino acids) with various 3-arylidene chroman-4-ones as dipolarophiles. The solvent effect on the 1,3-dipolar cycloaddition reaction is also studied.

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