CC BY ND NC 4.0 · SynOpen 2017; 01(01): 0024-0028
DOI: 10.1055/s-0036-1588810
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Microwave-Promoted Synthesis of 4-Arylpyrimidines by Pd-Catalysed Suzuki–Miyaura Coupling of 4-Pyrimidyl Tosylates in Water

José Rodríguez-Aguilar, Beatriz Ordóñez, Matías Vidal, Marcos Caroli Rezende, Moisés Domínguez*
  • Facultad de Química y Biología, Universidad de Santiago de Chile, Av. Bernardo O’Higgins 3363, Santiago, Chile   Email:
Supported by: Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT) (11140497)
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Publication History

Received: 08 March 2017

Accepted after revision: 09 April 2017

Publication Date:
25 April 2017 (online)


The Suzuki–Miyaura coupling reaction of 4-pyrimidyl tosylates was investigated with aryl, heteroaryl and alkyl boronic acids. The reaction provided 4-substituted pyrimidines in good-to-excellent yields after one-hour microwave irradiation in water at 100 °C. The method constitutes a fast option for the synthesis of these heterocyclic systems.

Supporting Information