Synlett
DOI: 10.1055/s-0036-1589096
letter
© Georg Thieme Verlag Stuttgart · New York

Rapid Continuous Ruthenium-Catalysed Transfer Hydrogenation of Aromatic Nitriles to Primary Amines

Ricardo Labesa, Davir González-Calderóna, Claudio Battilocchioa, Carlos Mateos*b, Graham R. Cummingb, Oscar de Frutosb, Juan A. Rincónb, Steven V. Ley*a
  • aInnovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK   Email: svl1000@cam.ac.uk
  • bCentro de Investigación Lilly S.A., Avda. de la Industria 30, Alcobendas-Madrid 28108, Spain   Email: c.mateos@lilly.com
This work was supported by Eli Lilly & Co. through the Lilly Research Award Program (LRAP). This work has also been funded by the EPSRC (SVL, grants EP/K009494/1, EP/M004120/1 and EP/K039520/1).
Further Information

Publication History

Received: 23 June 2017

Accepted after revision: 18 July 2017

Publication Date:
21 August 2017 (eFirst)

Dedicated to our friend Vic Snieckus on the occasion of his 80th birthday

Abstract

A continuous flow method for the selective reduction of aromatic nitriles to the corresponding amine is reported. The method is based on a ruthenium-catalysed transfer-hydrogenation process, requires no additives, and uses isopropanol as both solvent and reducing agent. The process utilizes 1 mol% of the commercially available [Ru(p-cymene)Cl2]2, with a residence time of ca. 9 min, and a throughput of 50 mmol/h. The method was successfully applied to a range of aromatic nitriles providing the corresponding primary amines in good yields.

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