Palladium-Catalyzed Arylation of Benzylic C–H Bonds of Azaarylmethanes with Aryl SulfidesThis work was supported by JSPS KAKENHI Grant Numbers JP16H01019, JP16H04109, JP16H06887, as well as JST ACT-C Grant Number JPMJCR12ZE, Japan. H.Y. thanks the Japan Association for Chemical Innovation, the Tokuyama Science Foundation, and The Naito Foundation for financial support. G.K. acknowledges a JSPS Postdoctoral Fellowship for Foreign Researchers.
Received: 26 June 2017
Accepted after revision: 17 July 2017
17 August 2017 (eFirst)
Dedicated to Professor Victor Snieckus in celebration of his 80th birthday
Benzylic C–H arylation of azaarylmethanes with aryl sulfides has been developed by using a Pd-NHC catalyst and an amide base. Various azaarylmethanes and aryl sulfides were involved in the reaction to afford the corresponding diarylmethanes in good to excellent yields. Moreover, triarylmethane synthesis was accomplished through iterative arylations of 2- or 4-methylpyridine with two different aryl sulfides.