DOI: 10.1055/s-0036-1590864
© Georg Thieme Verlag Stuttgart · New York

Syntheses of Dimeric Securinega Alkaloids

Sangbin Jeona, b, Joonoh Parka, b, Sunkyu Han*a, b
  • aDepartment of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea   Email:
  • bCenter for Catalytic Hydrocarbon Functionalizations, Institute for Basic Science (IBS), Daejeon 34141   Korea
This work was supported by Samsung Science and Technology Foundation under Project Number SSTF-BA1701-13.
Further Information

Publication History

Received: 11 June 2017

Accepted after revision: 11 July 2017

Publication Date:
22 August 2017 (eFirst)

This work is dedicated to Professor Jin Baek Kim on the occasion of his honorable retirement


The isolation of flueggenines A and B by Yue and co-workers in 2006 has triggered a burst of isolation reports of dimeric and oligomeric securinega alkaloid natural products. The compelling molecular structures of these compounds with various modes of connection between monomeric securinega units have posed intriguing challenges to the synthetic organic community. Herein, we have categorized high-order securinega alkaloids based on their biosynthetic mode of dimerization or oligomerization. We then have compiled all reported syntheses of dimeric securinega alkaloids based on our classification.

1 Introduction

2 Categorization of High-Order Securinega Alkaloid Natural Products

3 Syntheses of Type I Dimeric Securinega Alkaloids

4 Syntheses of Type II Dimeric Securinega Alkaloids

5 Synthesis of Type III Dimeric Securinega Alkaloid

6 Conclusion