Facile Synthesis of 3-Amido-Dienynes via a Tandem α-Propargylation–Isomerization of Chiral Allenamides and their Applications in Diels–Alder CycloadditionsThe authors thank NIH (GM-66055) for generous funding. Authors also thank UW-Madison Medicinal Chemistry Center for financial support. RPH thanks Laura and Edward Kremers Family Foundation for a generous endowed chair in natural products chemistry.
Received: 08 June 2017
Accepted after revision: 11 August 2017
01 September 2017 (eFirst)
With deep respect and admiration, this paper is dedicated to Professor Victor Snieckus on the special occasion of his 80th birthday
A series of interesting 3-amido-dienynes was synthesized via tandem α-propargylation–isomerization of chiral allenamides with moderate E/Z ratio. Reactivities of E and Z isomers were examined.