New Strategy for Forging Contiguous Quaternary Carbon Centers via H2O2-Mediated Ring ContractionWe are grateful for ﬁnancial support from the National Natural Science Foundation of China (grants. 21722206, 21672171, 21372239), the Scientific Research Foundation of Northwest A&F University (grants. Z111021501, Z109021600). Financial support from the Open Fund of State Key Laboratory of Bioorganic & Natural Products is also acknowledged.
Received: 25 July 2017
Accepted after revision: 24 August 2017
12 September 2017 (eFirst)
Stereospecific construction of contiguous quaternary carbon centers constitutes a major challenge in natural product synthesis. A general protocol that enables stereospecific construction of all stereoisomers of such a moiety remains elusive. In this article, we will discuss the oxidative ring contraction of all-substituted cyclic α-formyl ketones mediated by H2O2, which provides a facile access to the stereospecific construction of contiguous quaternary carbon centers.