DOI: 10.1055/s-0036-1590979
© Georg Thieme Verlag Stuttgart · New York

New Strategy for Forging Contiguous Quaternary Carbon Centers via H2O2-Mediated Ring Contraction

Jiadong Hua, Xin Yub, Weiqing Xie*a, c
  • aShaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, 22 Xinong Road, Yangling 712100, Shaanxi, P. R. of China   Email:
  • bInstrumental Analysis and Research Center, Shanghai University, Shanghai 200444, P. R. of China
  • cKey Laboratory of Botanical Pesticide R&D in Shaanxi Province, Yangling, Shaanxi 712100, P. R. of China
We are grateful for financial support from the National Natural Science Foundation of China (grants. 21722206, 21672171, 21372239), the Scientific Research Foundation of Northwest A&F University (grants. Z111021501, Z109021600). Financial support from the Open Fund of State Key Laboratory of Bioorganic & Natural Products is also acknowledged.
Further Information

Publication History

Received: 25 July 2017

Accepted after revision: 24 August 2017

Publication Date:
12 September 2017 (eFirst)


Stereospecific construction of contiguous quaternary carbon centers constitutes a major challenge in natural product synthesis. A general protocol that enables stereospecific construction of all stereoisomers of such a moiety remains elusive. In this article, we will discuss the oxidative ring contraction of all-substituted cyclic α-formyl ketones mediated by H2O2, which provides a facile access to the stereospecific construction of contiguous quaternary carbon centers.