[4+3]-Annulation of 3-Cyano-4-aryl-2-iminochromenes with 1,2-Diaminobenzene: An Access to Novel Chromenobenzodiazepines

Abstract

3-Cyano-4-aryl-2-iminochromenes undergo [4+3]-annulation with 1,2-diaminobenzene under mild acidic conditions to generate novel chromenobenzodiazepines in good yields. The annulation reaction was also successful with 2-aminophenol and 2-aminothiophenol. The chromenobenzodiazepines could be conveniently reduced to the corresponding 4H-chromenobenzodiazepines under mild acidic conditions.

Key words

3-cyano-4-aryl-2-iminochromene - 1,2-diaminobenzene - [4+3]-annulation - chromenobenzodiazepine - chromenobenzoazepine

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