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CC BY-ND-NC 4.0 · SynOpen 2018; 02(01): 0017-0024
DOI: 10.1055/s-0036-1591754
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Design, Synthesis, and Cytotoxic Evaluation of Etodolac-1,3,4-oxadiazole-1,2,3-triazole Molecules

Bhaskar Kummari
a   Centre for Chemical Sciences and Technology Institute of Science and Technology, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500085, T.S., India   Email: jayashreeaniredy@gmail.com
,
Perla Ramesh 
b   Natural Products Chemistry Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500007, T.S., India
,
Naveen Polkam
a   Centre for Chemical Sciences and Technology Institute of Science and Technology, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500085, T.S., India   Email: jayashreeaniredy@gmail.com
,
Shankaraiah Malthum
a   Centre for Chemical Sciences and Technology Institute of Science and Technology, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500085, T.S., India   Email: jayashreeaniredy@gmail.com
,
M. V. P. S. Vishnuvardhan
c   Medicinal chemistry and biotechnology, Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500007, T.S., India
,
Jaya Shree Anireddy*
a   Centre for Chemical Sciences and Technology Institute of Science and Technology, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500085, T.S., India   Email: jayashreeaniredy@gmail.com
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Further Information

Publication History

Received: 03 November 2017

Accepted after revision: 24 December 2017

Publication Date:
29 January 2018 (online)

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Abstract

A new series of etodolac-1,3,4-oxadiazole-1,2,3-triazole derivatives was designed and synthesized from commercially available starting materials by employing a simple synthetic sequence. The in vitro evaluation of the synthesized analogues displayed promising cytotoxic activity. Among the tested compounds 7c, 7l, and 7n exhibited highest cytotoxic activity against MCF-7 (breast), A549 (lung), and DU-145 (prostate) human cancer cell lines.

Key words

synthesis - etodolac - oxadiozoles - triazoles - cytotoxicity

Supporting Information

    Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591754.
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