Synlett 2018; 29(01): 01-07
DOI: 10.1055/s-0036-1591862
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© Georg Thieme Verlag Stuttgart · New York

A Comparative Assessment of Modern Cyclization Methods of Substituted Alkynyl Esters, Ethers, and Acids

Yashar Soltani
School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, Cymru/Wales, UK   Email: MelenR@cardiff.ac.uk
,
Lewis C. Wilkins
School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, Cymru/Wales, UK   Email: MelenR@cardiff.ac.uk
,
Rebecca L. Melen*
School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, Cymru/Wales, UK   Email: MelenR@cardiff.ac.uk
› Author Affiliations
Further Information

Publication History

Received: 22 October 2017

Accepted after revision: 16 November 2017

Publication Date:
11 December 2017 (online)

These authors contributed equally

Abstract

Naturally occurring heterocycles such as pyrones, dihydropyrones, and isocoumarins have proven to be highly active biological agents with a vast plethora of applications. Therefore, their synthesis has attracted mentionable notice in recent decades. Of particular synthetic use is the cyclization of substituted alkynyl esters. More recently, main group compounds have been studied to affect this synthetic pathway giving access to a large family of heterocyclic derivatives.

 
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