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J Pediatr Intensive Care 2017; 06(03): 152-158
DOI: 10.1055/s-0036-1593886
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Persistent Hyperlactatemia as the Predictor of Poor Outcome in Critically Ill Children: A Single-Center, Prospective, Observational Cohort Study

Vinayak K. Patki
1   Department of Pediatrics, Institute of Medical Education and Research, Vidyagiri, Satara, Maharashtra, India
,
Jennifer V. Antin
2   Department of Pediatrics, Wanless Hospital, Miraj, Sangli, Maharashtra, India
,
Shweta H. Khare
2   Department of Pediatrics, Wanless Hospital, Miraj, Sangli, Maharashtra, India
› Author Affiliations
Further Information

Publication History

26 February 2016

28 September 2016

Publication Date:
10 November 2016 (online)

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Abstract

Objective To study incidence of hyperlactatemia and its correlation with outcome in critically ill children.

Design Single-center, prospective cohort study.

Setting Eight-bedded PICU.

Method Serial serum lactate levels were measured in 140 critically ill children at 0, 12, 24, and 48 hours.

Results A total of 45% children had hyperlactatemia. Lactate levels were significantly (p = 0.000) higher in nonsurvivors at all intervals. Lactate levels decreased significantly (p = 0.000) in survivors while increased in nonsurvivors. Normalized lactate load was found to be an independent predictor of mortality (p = 0.023).

Conclusion Persistent hyperlactatemia serves as a possible predictor of poor outcome in critically ill children.

Keywords

critically ill children - hyperlactatemia - PICU - PRISM - normalized lactate load
 

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