J Pediatr Infect Dis 2017; 12(02): 142-144
DOI: 10.1055/s-0036-1597691
Case Report
Georg Thieme Verlag KG Stuttgart · New York

A Case of Herpes Zoster and Meningitis in a Twice-Vaccinated Healthy Adolescent

Yih-Chieh Chen*
1  Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, United States
,
Aisha James*
1  Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, United States
2  Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States
,
Emily Kung
3  Division of Pediatric Hospitalist Medicine, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, United States
,
Vandana Madhavan
3  Division of Pediatric Hospitalist Medicine, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, United States
4  Division of Pediatric Infectious Disease, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, United States
› Author Affiliations
Further Information

Publication History

20 October 2016

26 November 2016

Publication Date:
01 March 2017 (online)

Abstract

Since the adoption of the varicella-zoster virus (VZV) vaccine, the incidence of varicella infections of all types has declined. Although uncommon, local cutaneous herpes zoster secondary to vaccine-strain VZV has been well documented in healthy children. However, there are few reports of vaccine-strain VZV central nervous system disease in this same population. We present a case of a previously healthy twice-VZV vaccinated 14-year-old girl who presented with rash and headache who was found to have herpes zoster complicated by meningitis. Cerebrospinal fluid polymerase chain reaction confirmed zoster infection secondary to reactivation of vaccine-strain VZV. Her disease course and response to therapy are reviewed.

* These authors contributed equally to this work.