CC BY-NC-ND 4.0 · Journal of Child Science 2017; 07(01): e89-e95
DOI: 10.1055/s-0037-1603895
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Sepsis Biomarkers in Neonates and Children: C-Reactive Protein and Procalcitonin

J. Markic
1   University of Split School of Medicine, Split, Croatia
2   Department of Pediatrics, University Hospital of Split, Split, Croatia
M. Saraga
1   University of Split School of Medicine, Split, Croatia
2   Department of Pediatrics, University Hospital of Split, Split, Croatia
P. Dahlem
3   Department of Pediatrics, Medical Center Coburg, Academic Hospital of the University of Split, Coburg, Germany
› Author Affiliations
Further Information

Publication History

10 June 2016

07 March 2017

Publication Date:
26 July 2017 (online)


Bacteremia and sepsis are still significant causes of morbidity and mortality among children and neonates worldwide. Early recognition of bacterial sepsis and initiation of therapy is associated with better treatment outcomes but is challenging as many of the early clinical features can be similar to those in self-limiting viral illnesses. Diagnosis of bacteremia is also challenging because the use of blood culture, the gold standard for diagnosis of bacteremia, is fraught with difficulties. Therefore, various biomarkers are of great importance in the process of diagnosis of sepsis and evaluation of its severity. They can indicate the presence or absence or severity of sepsis and are helpful in differentiating bacterial from viral and fungal infection. Of the many proposed biomarkers for infection and/or sepsis, acute-phase proteins such as C-reactive protein (CRP) and procalcitonin (PCT) are widely used and have perhaps been most widely assessed. In this review, we will present the advantages and disadvantages of CRP and PCT determination in sepsis evaluation. It will be presented that it is still not always possible to predict accurately the presence of bacterial infection on the basis of clinical appearance and available laboratory tests. Therefore, the investigation of new and better biomarkers is challenging and ongoing.

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