CC BY-NC-ND 4.0 · Journal of Child Science 2017; 07(01): e106-e109
DOI: 10.1055/s-0037-1604476
Rapid Communication
Georg Thieme Verlag KG Stuttgart · New York

Low Gestational Age Is the Strongest Predictor for Severe Retinopathy of Prematurity and Adverse Outcomes at Two-Year Follow-Up in a Low Incidence Setting

Stefano Nobile
1   Division of Neonatology, Department of Mother and Child Health, Salesi Children's Hospital, Ancona, Italy
Linda Bordignon
1   Division of Neonatology, Department of Mother and Child Health, Salesi Children's Hospital, Ancona, Italy
Anna Maria Peretti
1   Division of Neonatology, Department of Mother and Child Health, Salesi Children's Hospital, Ancona, Italy
Virgilio Paolo Carnielli
1   Division of Neonatology, Department of Mother and Child Health, Salesi Children's Hospital, Ancona, Italy
› Author Affiliations
Further Information

Publication History

01 May 2017

03 July 2017

Publication Date:
04 August 2017 (online)


We aimed to determine the risk factors for type 1 ROP and outcomes at 2 years of corrected age among preterms born < 30 weeks of gestational age (GA) in a low-incidence setting. A cohort study with 447 infants was conducted. Those who underwent laser therapy for type 1 ROP were compared with controls by univariate and multivariate analysis. Neurological development was assessed by Bayley scales. Using univariate analysis, gestational age, sepsis, necrotizing enterocolitis, and insulin administration were found to be associated with type 1 ROP. Only GA remained significant with logistic regression. Infants with type 1 ROP had worse visual and neurodevelopmental outcomes at 2 years. Predictors of impaired neurodevelopment were type 1 ROP, surfactant administration, and bronchopulmonary dysplasia. Low GA was found to be a strong predictor of type 1 ROP, which was associated (along with surfactant administration and bronchopulmonary dysplasia) with worse neurological development.

  • References

  • 1 Mezer E, Chetrit A, Kalter-Leibovici O, Kinori M, Ben-Zion I, Wygnanski-Jaffe T. Trends in the incidence and causes of severe visual impairment and blindness in children from Israel. J AAPOS 2015; 19 (03) 260-5.e1
  • 2 Stoll BJ, Hansen NI, Bell EF. , et al; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Neonatal outcomes of extremely preterm infants from the NICHD neonatal research network. Pediatrics 2010; 126 (03) 443-456
  • 3 Lundgren P, Kistner A, Andersson EM. , et al. Low birth weight is a risk factor for severe retinopathy of prematurity depending on gestational age. PLoS One 2014; 9 (10) e109460
  • 4 Catenacci M, Miyagi S, Wickremasinghe AC. , et al. Dopamine-resistant hypotension and severe retinopathy of prematurity. J Pediatr 2013; 163 (02) 400-405
  • 5 Binenbaum G. Algorithms for the prediction of retinopathy of prematurity based on postnatal weight gain. Clin Perinatol 2013; 40 (02) 261-270
  • 6 Mohamed S, Murray JC, Dagle JM, Colaizy T. Hyperglycemia as a risk factor for the development of retinopathy of prematurity. BMC Pediatr 2013; 13: 78
  • 7 Tolsma KW, Allred EN, Chen ML, Duker J, Leviton A, Dammann O. Neonatal bacteremia and retinopathy of prematurity: the ELGAN study. Arch Ophthalmol 2011; 129 (12) 1555-1563
  • 8 Nobile S, Gnocchini F, Pantanetti M, Battistini P, Carnielli VP. The importance of oxygen control reaffirmed: experience of ROP reduction at a single tertiary care center. J Pediatr Ophthalmol Strabismus 2014; 51 (02) 112-115
  • 9 Owen LA, Morrison MA, Hoffman RO, Yoder BA, DeAngelis MM. Retinopathy of prematurity: a comprehensive risk analysis for prevention and prediction of disease. PLoS One 2017; 12 (02) e0171467
  • 10 Axer-Siegel R, Maharshak I, Snir M. , et al. Diode laser treatment of retinopathy of prematurity: anatomical and refractive outcomes. Retina 2008; 28 (06) 839-846
  • 11 Gole GA, Ells AL, Katz X. , et al; International Committee for the Classification of Retinopathy of Prematurity. The international classification of retinopathy of prematurity revisited. Arch Ophthalmol 2005; 123 (07) 991-999
  • 12 Bayley N. Bayley scales of infant and toddler development. 3rd ed. San Antonio, TX: Pearson; 2006
  • 13 Walsh MC, Wilson-Costello D, Zadell A, Newman N, Fanaroff A. Safety, reliability, and validity of a physiologic definition of bronchopulmonary dysplasia. J Perinatol 2003; 23 (06) 451-456
  • 14 Poggi C, Giusti B, Gozzini E. , et al. Genetic contributions to the development of complications in preterm newborns. PLoS One 2015; 10 (07) e0131741
  • 15 Trittmann JK, Nelin LD, Klebanoff MA. Bronchopulmonary dysplasia and neurodevelopmental outcome in extremely preterm neonates. Eur J Pediatr 2013; 172 (09) 1173-1180