Abstract
Introduction Antenatal magnesium sulfate (MgSO4) administration has shown to be effective in minimizing cerebral palsy and severe
motor dysfunction at the age of 2 years. The aim of this study is to determine the
relationship between the magnesium dose delivered to the mother and the magnesium
concentration in the neonates.
Materials and Methods A prospective cohort study was conducted on neonates of less than 32 weeks' gestation
admitted to the neonatal intensive care unit of University Hospital Complex of Vigo
from December 2012 to July 2015. Comparative analysis of magnesium levels between
the groups of neonates exposed to MgSO4 and the control group.
Results A total of 118 neonates were included in the study. The mothers of 62 of them had
received MgSO4 as a neuroprotective agent. There was a significant correlation between the full
dose of MgSO4 received by the mother and the levels of magnesium in the neonate in the first 24
hours of life (r
2 = 0.397; p < 0.001).
Conclusion The MgSO4 dose received by the mother has a linear relationship with the magnesium levels obtained
in neonates.
Keywords
magnesium sulfate - neuroprotection - serum magnesium concentration - maternal dose
