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Topical anti-inflammatory activity of the hydroethanolic extract from Kalanchoe brasiliensis Cambess. (Crassulaceae) leaves
24 October 2017 (online)
Kalanchoe brasiliensis Cambess. (Crassulaceae), known as “saião”, is a plant used in folk medicine for the treatment of inflammation, injuries, abscesses, and enlarged ganglia.1,2 The present study evaluated the topical anti-inflammatory effect of the hydroethanolic extracts EHJ50 (50%) and EHJ70 (70%) obtained from K. brasiliensis leaves. Using doses of 0.10, 0.50 and 1.0 mg/ear of the extracts, the anti-inflammatory activity was assessed by Croton oil-induced acute ear edema method3, determination of inflammatory enzymes (MPO and NAG) and proinflammatory mediators (NO, IL-6 and TNF-α) and histopathological analysis. After 24h of treatment with EHJ50 and EHJ70, the inhibition of ear edema ranged from 62.03 to 80.34%. These extracts also reduced MPO (55.27 to 81.74%) and NAG (69.04 to 80.82%), while the NO levels decreased from 46.74 to 67.43%. The dose of 1.0 mg/ear was able to inhibit IL-6 (EHJ50 = 20.59% and EHJ70 = 22.78%) and TNF-α (EHJ50 = 16.71% and EHJ70 = 23.71%). These results suggest that K. brasiliensis has topical anti-inflammatory effect and can be a promising source for the development of phytotherapics for skin disorders.
This investigation was supported by UFJF, FAPEMIG, CAPES, OEA and GCUB.
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