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CC BY-ND-NC 4.0 · SynOpen 2018; 02(04): 0298-0305
DOI: 10.1055/s-0037-1610399
DOI: 10.1055/s-0037-1610399
paper
Efficient One-Pot Synthesis of Triazole-Linked Morpholinone Scaffolds by CuAAC in the Presence of 18-Crown-6
Further Information
Publication History
Received: 08 October 2018
Accepted after revision: 02 November 2018
Publication Date:
22 November 2018 (online)
Abstract
A range of bis-heterocyclic derivatives based on novel morpholinone and triazole heterocycles was prepared from iodo-morpholinone. The key step in our strategy is a one-pot procedure based upon copper-catalysed alkyne-azide cycloaddition (CuAAC) from iodo-morpholinone.
Key words
click chemistry - iodolactonization - morpholinones - azides - 1,2,3-triazole - one-pot procedureSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610399.
- Supporting Information
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For recent iodocyclizations, see: