Palladium-Catalysed Coupling and Acid-Mediated Cyclisation: Synthesis of Fluorenones and Fluorenes

Abstract

Palladium-catalysed sequential one-pot synthesis of fluorenones is described. The reaction comprises intermolecular Suzuki coupling and intramolecular acid-mediated cyclisation in a one-pot procedure. The protocol is also applied to the synthesis of fluorenes using a single column purification.

Key words

Friedel–Crafts - cyclocarbonylation - fluorenone - fluorine

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