Synlett 2019; 30(09): 1003-1007
DOI: 10.1055/s-0037-1610699
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© Georg Thieme Verlag Stuttgart · New York

Potassium Alkoxide/Disilane-Mediated Dehalogenative Deuteration

Xin Wang
,
Ming-Hui Zhu
,
Wen-Bo Liu*
Engineering Research Center of Organosilicon Compounds & Materials, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, 299 Bayi Rd, Wuhan, Hubei, 430072, P. R. of China   Email: wenboliu@whu.edu.cn
› Author Affiliations
We thank the National Natural Science Foundation of China (21602160 and 21772148), Wuhan University (2042018kf0017), the Fundamental Research Funds for the Central Universities and the National Program for 1000 Young Talents of China for financial support of this research.
Further Information

Publication History

Received: 27 January 2019

Accepted after revision: 18 February 2019

Publication Date:
19 March 2019 (online)

Abstract

Deuterated compounds are of great importance in chemistry and pharmaceuticals. Reductive dehalogenation is one of the most useful methods to incorporate deuterium into molecules. This article briefly discusses the historical development of dehalogenative deuteration reactions that involve transition-metal catalysis, radical halogen abstraction, alkali-metal reductive deuteration, and the recently developed potassium methoxide/hexamethyldisilane-mediated dehalogenation of aryl halides.

 
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