Synlett 2019; 30(09): 1008-1014
DOI: 10.1055/s-0037-1612214
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© Georg Thieme Verlag Stuttgart · New York

Enantioselective Reductive Diarylation of Alkenes by Ni-Catalyzed Domino Heck Cyclization/Cross Coupling

Kuai Wang
,
The Center for Precision Synthesis, Institute for Advanced Studies, Wuhan University, Wuhan, 430072, P. R. of China   Email: wqkong@whu.edu.cn
› Author Affiliations
We acknowledge financial support from the ‘1000-Youth Talents Plan’, National Natural Science Foundation of China (No. 21702149) and Fundamental Research Funds for the Central Universities (2042018kf0012).
Further Information

Publication History

Received: 19 December 2018

Accepted after revision: 21 January 2019

Publication Date:
18 February 2019 (online)

Abstract

A Ni-catalyzed enantioselective reductive diarylation of alkenes through a tandem Heck cyclization/cross coupling of two structurally distinguished aryl bromides is accomplished for the first time. This reaction takes place under very mild conditions with high efficiency and tolerates a variety of functional groups. Thus, it provides a rapid access to various medicinally relevant bis-heterocycles containing all-carbon quaternary centers with very high enantioselectivity.

 
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