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Thromb Haemost 1998; 79(02): 359-361
DOI: 10.1055/s-0037-1614992
Letters to the Editor
Schattauer GmbH

The Histidin-rich Glycoprotein Pro186/Ser Polymorphism Is not Related to Myocardial Infarction in the ECTIM Study

Authors

  • Stefan-Martin Herrmann

    1   Institut National de la Santé et de la Recherche Médicale (INSERM) SC7, Paris, INSERM U258, Paris

  • Odette Poirier

    1   Institut National de la Santé et de la Recherche Médicale (INSERM) SC7, Paris, INSERM U258, Paris

  • Viviane Nicaud

    1   Institut National de la Santé et de la Recherche Médicale (INSERM) SC7, Paris, INSERM U258, Paris

  • Jean-Bernard Ruidavets

    2   MONICA Project Toulouse, France

  • Alun Evans

    3   MONICA Project Belfast, UK

  • Dominique Arveiler

    4   MONICA Project Strasbourg

  • Gerald Luc

    5   MONICA Project Lille

  • Lucienne Bara

    6   Laboratoire de Thrombose Expérimentale, Université Paris VI, France

  • François Cambien

    1   Institut National de la Santé et de la Recherche Médicale (INSERM) SC7, Paris, INSERM U258, Paris
Further Information

Publication History

Received 16 April 1997

Accepted after resubmission 17 September 1997

Publication Date:
08 December 2017 (online)

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Summary

The histidin-rich glycoprotein (HRG) may contribute to coronary heart disease as a consequence of its possible thrombophilic properties. To test this hypothesis we have investigated the Pro186/Ser polymorphism of the HRG gene, which is known to strongly affect plasma HRG levels, in a large multicenter case-control study of myocardial infarction (MI). The results failed to demonstrate any association between the polymorphism and MI or angiographically assessed coronary stenosis.

 

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