Expression of Fibrinogen Receptors in Platelets of Migraine Patients - Correlation with Platelet GPIIb Content and Plasma Cholesterol

Summary

Binding of fibrinogen to platelets washed from blood of migraine patients (n = 30) and control donors (n = 24) was compared. In addition, contents of platelet glycoprotein IIb and platelet fibrinogen were determined in both groups by radioimmunoassay. The receptor capacity for fibrinogen in platelets activated by ADP was significantly higher (p <0.01) in migraine patients (52,505 α 4,925) than in controls (33,881 λ 3,965). The mean contents of GPIIb (3.51 α 0.34 μg/10⁸ platelets) and fibrinogen (37 .26 α 4.05 μg/10⁸ platelets) in migraine platelets were also markedly increased (p <0.01 and p <0.001, respectively) when compared to controls (2.21 α 0.18 μg of GPIIb ano 18.75 λ 2.29 μE of fibrinogen per 10⁸ platelets, respectively). There was a high correlation between the number of fibrinogen receptors exposed by ADP and the total amount of platelet GPIIb both in migraineurs (R = 0.69, p <0.01) and controls (R = 0.62, p <0.01,), as well as plasma cholesterol in the case of migraine patients (R = 0.82, p <0.001)

Keywords

Fibrinogen receptors - Glycoprotein IIb/IIIa complex - Cholesterol - Migraine

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