Posterior Reversible Encephalopathy Syndrome Complicating Ruptured Appendicitis and Abscess Drainage in a Previously Healthy Pediatric Patient

Taylor Saley; Alexander Barton; Shawn Berry Sood; Roopa Thukaram

doi:10.1055/s-0038-1668603

Journal of Pediatric Intensive Care, Inhaltsverzeichnis

J Pediatr Intensive Care 2019; 08(02): 092-095
DOI: 10.1055/s-0038-1668603

Case Report

Georg Thieme Verlag KG Stuttgart · New York

Posterior Reversible Encephalopathy Syndrome Complicating Ruptured Appendicitis and Abscess Drainage in a Previously Healthy Pediatric Patient

Authors

Taylor Saley

¹Department of Pediatrics, University of Oklahoma School of Community Medicine, Tulsa, Oklahoma, United States
Alexander Barton

²UGTA, Department of Biology, The University of Oklahoma, Norman, Oklahoma, United States
Shawn Berry Sood

³Division of Pediatric Critical Care, Vanderbilt University School of Medicine, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee, United States
Roopa Thukaram

⁴Division of Pediatric Intensive Care, The Children's Hospital at Saint Francis, 6161 South Yale Avenue, Tulsa, Oklahoma, United States

Abstract

In this study, we present the youngest reported case of posterior reversible encephalopathy syndrome (PRES) in the United States, which developed following perforated appendicitis with subsequent peritonitis and intra-abdominal abscess formation. Additionally, we discuss potential physiological factors contributing to her acute neurological deterioration and resultant cerebral vasogenic edema.

Keywords

autoregulation - endothelium - seizures - sepsis - PRES

Volltext

Referenzen

References
1 Hinchey J, Chaves C, Appignani B. , et al. A reversible posterior leukoencephalopathy syndrome. N Engl J Med 1996; 334 (08) 494-500
2 Ettinger N, Pearson M, Lamb FS, Wellons III JC. Pediatric posterior reversible encephalopathy syndrome presenting with isolated cerebellar edema and obstructive hydrocephalus. J Neurosurg Pediatr 2014; 14 (04) 344-347
3 Raj S, Overby P, Erdfarb A, Ushay HM. Posterior reversible encephalopathy syndrome: incidence and associated factors in a pediatric critical care population. Pediatr Neurol 2013; 49 (05) 335-339
4 Bartynski WS. Posterior reversible encephalopathy syndrome, part 1: fundamental imaging and clinical features. Am J Neuroradiol 2008; 29 (06) 1036-1042
5 Bolton SJ, Anthony DC, Perry VH. Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood-brain barrier breakdown in vivo. Neuroscience 1998; 86 (04) 1245-1257
6 Pfister D, Siegemund M, Dell-Kuster S. , et al. Cerebral perfusion in sepsis-associated delirium. Crit Care 2008; 12 (03) R63
7 Vallet B. Bench-to-bedside review: endothelial cell dysfunction in severe sepsis: a role in organ dysfunction?. Crit Care 2003; 7 (02) 130-138
8 Fugate JE, Rabinstein AA. Posterior reversible encephalopathy syndrome: clinical and radiological manifestations, pathophysiology, and outstanding questions. Lancet Neurol 2015; 14 (09) 914-925
9 Vavilala MS, Newell DW, Junger E. , et al. Dynamic cerebral autoregulation in healthy adolescents. Acta Anaesthesiol Scand 2002; 46 (04) 393-397
10 Siebert E, Bohner G, Endres M, Liman TG. Clinical and radiological spectrum of posterior reversible encephalopathy syndrome: does age make a difference?--A retrospective comparison between adult and pediatric patients. PLoS One 2014; 9 (12) e115073
11 Zheng W. Neurotoxicology of the brain barrier system: new implications. J Toxicol Clin Toxicol 2001; 39 (07) 711-719