CC BY 4.0 · Surg J (N Y) 2018; 04(03): e164-e166
DOI: 10.1055/s-0038-1669991
Case Report
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Olfactory Nerve Schwannoma: A Case Report and Review of the Literature

Mahmoud M. Taha
1   Department of Neurosurgery, Zagazig University, Zagazig, Egypt
Amr AlBakry
1   Department of Neurosurgery, Zagazig University, Zagazig, Egypt
Magdy ElSheikh
1   Department of Neurosurgery, Zagazig University, Zagazig, Egypt
Tarek H. AbdelBary
1   Department of Neurosurgery, Zagazig University, Zagazig, Egypt
› Author Affiliations
Further Information

Publication History

02 April 2018

09 August 2018

Publication Date:
10 September 2018 (online)


Schwannomas are benign tumors, which arise from the Schwann cells of the central or peripheral nerves. They form 8% of all intracranial tumors and most of the cases arise from vestibular division of the 8th cranial nerve. Rare cases are shown to arise from the olfactory or optic nerve, being devoid of myelin sheath. Up to date and according to our best of knowledge, 66 cases have been reported till now. Here we present a review of the literature and a case report of a 56-year-old male with an accidently discovered anterior cranial fossa schwannoma, following a road traffic accident. Tumor was completely excised, using a right frontal approach. Histopathology revealed Antoni-A cellular pattern. Although rare, but olfactory nerve schwannomas should be included in the differential diagnosis in anterior cranial fossa space occupying lesions, and the approach should be designed taking into consideration, this rare entity.

  • References

  • 1 Esquivel-Miranda M, De la O Ríos E, Vargas-Valenciano E, Moreno-Medina E. [Anterior skull-base schwannoma]. Neurocirugia (Astur) 2017; 28 (06) 298-305
  • 2 Figueiredo EG, Soga Y, Amorim RL, Oliveira AM, Teixeira MJ. The puzzling olfactory groove schwannoma: a systematic review. Skull Base 2011; 21 (01) 31-36
  • 3 Manto A, Manzo G, De Gennaro A, Martino V, Buono V, Serino A. An enigmatic clinical entity: A new case of olfactory schwannoma. Neuroradiol J 2016; 29 (03) 174-178
  • 4 Figueroa-Angel V, Rodríguez-Aceves CA, Calderon-Miranda WG, Escobar-Hernandez N, Joaquim AF, Moscote-Salazar LR. Subfrontal schwannoma: case report and review of literature. World Neurosurg 2017; 111: 386-390
  • 5 Quick J, Hattingen E, Delbridge C, Seifert V, Marquardt G. Schwannoma of the olfactory nerve. Report of two cases and review of the literature. Clin Neurol Neurosurg 2015; 132: 44-46
  • 6 Adachi K, Yoshida K, Miwa T, Ikeda E, Kawase T. Olfactory schwannoma. Acta Neurochir (Wien) 2007; 149 (06) 605-610 , discussion 610–611
  • 7 Micovic MV, Zivkovic BM, Zivanovic JD, Bascarevic VL, Bogosavljevic V, Rasulic LG. Ancient olfactory schwannoma-case report and literature review. Turk Neurosurg 2017; 27 (04) 656-651
  • 8 Chuah MI, Au C. Olfactory schwann cells are derived from precursor cells in the olfactory epithelium. J Neurosci Res 1991; 29 (02) 172-180
  • 9 Ahmad FU, Gupta A, Sharma MC, Shukla G, Mehta VS. The enigmatic origin of subfrontal schwannomas: report of a case without hyposmia. Acta Neurochir (Wien) 2006; 148 (06) 671-672 , discussion 672
  • 10 Huang PP, Zagzag D, Benjamin V. Intracranial schwannoma presenting as a subfrontal tumor: case report. Neurosurgery 1997; 40 (01) 194-197
  • 11 Okamoto H, Mineta T, Wakamiya T. , et al. Two cases of subfrontal schwannoma, including a rare case located between the endosteal and meningeal layers of the dura. Neurol Med Chir (Tokyo) 2014; 54 (08) 681-685
  • 12 Daglioglu E, Okay O, Dalgic A, Albayrak AL, Ergungor F. Cystic olfactory schwannoma of the anterior cranial base. Br J Neurosurg 2008; 22 (05) 697-699
  • 13 Blake DM, Husain Q, Kanumuri VV, Svider PF, Eloy JA, Liu JK. Endoscopic endonasal resection of sinonasal and anterior skull base schwannomas. J Clin Neurosci 2014; 21 (08) 1419-1423
  • 14 Fujii T, Otani N, Doi K. , et al. [Surgical treatment of a giant olfactory groove schwannoma:a case report]. No Shinkei Geka 2017; 45 (10) 919-928
  • 15 Kanaan HA, Gardner PA, Yeaney G. , et al. Expanded endoscopic endonasal resection of an olfactory schwannoma. J Neurosurg Pediatr 2008; 2 (04) 261-265
  • 16 Liu JK, Eloy JA. Expanded endoscopic endonasal transcribriform approach for resection of anterior skull base olfactory schwannoma. Neurosurg Focus 2012; 32 (Suppl. 01) E3
  • 17 Pereira MC, Peris-Celda M, Qian J, Kenning TJ, Pinheiro-Neto CD. Unilateral endoscopic endonasal surgery for resection of an olfactory schwannoma of the anterior cranial base in a patient with hereditary hemorrhagic telangiectasia. World Neurosurg 2016; 89: 729.e15-729.e20