Am J Perinatol 2019; 36(10): 1072-1078
DOI: 10.1055/s-0038-1675644
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Systemic Arterial Hypertension in Childhood: A Challenge Related to the Increasing Survival of Very Low Birth Weight Preterm Infants

Bruna Ossanai Schoenardie
1   Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
,
Victória Bernardes Guimarães
2   School of Medicine, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil
,
Renato Soibelmann Procianoy
3   Department of Pediatrics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
4   Neonatology Section, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
,
Rita C. Silveira
3   Department of Pediatrics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
4   Neonatology Section, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
› Author Affiliations
Further Information

Publication History

18 July 2018

25 September 2018

Publication Date:
11 December 2018 (online)

Abstract

Objective To verify the prevalence of systemic arterial hypertension (SAH) and to identify possible early predictors of SAH at ages 2 and 4 years in very low birth weight (VLBW) infants.

Study Design This is a prospective cohort study including inborn children with birth weight (BW) <1,500 g. Arterial blood pressure measurements were performed at 2 and 4 years. Model 1 compared children with and those without SAH at age 4. Model 2 compared children who had SAH at ages 2 and 4 with the others. SAH was diagnosed if the systolic or/and diastolic pressures were above the 95th percentile.

Results A total of 198 patients were included during the 5-year study period, of whom 56% had SAH at age 4. In model 1, white matter injury (WMI) and catch-up growth at age 2 were predictors of SAH at age 4. In model 2, bronchopulmonary dysplasia, WMI, catch-up growth at age 2, and BW were predictors of SAH at 2 and 4 years. SAH at age 2 was an independent risk factor for SAH at age 4. After a multivariate analysis of model 2, BW and catch-up growth were associated with SAH.

Conclusion Prevalence of SAH was high in VLBW infants; it was associated with low BW and catch-up growth at age 2.

 
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