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Am J Perinatol 2020; 37(05): 491-496
DOI: 10.1055/s-0039-1683438
Original Article

The Effect of Antenatal Vaginal Progesterone Administration on Uterine, Umbilical, and Fetal Middle Cerebral Artery Doppler Flow: A Cohort Study

Ahmed M. Maged
1   Department of Obstetrics and Gynecology, Kasr Alainy Hospital, Cairo University, Cairo, Egypt
,
Amira Y. Shoab
1   Department of Obstetrics and Gynecology, Kasr Alainy Hospital, Cairo University, Cairo, Egypt
,
Eman A. Hussein
1   Department of Obstetrics and Gynecology, Kasr Alainy Hospital, Cairo University, Cairo, Egypt
,
Ahmed H. Alsawaf
1   Department of Obstetrics and Gynecology, Kasr Alainy Hospital, Cairo University, Cairo, Egypt
,
Doaa S. Mahmoud
1   Department of Obstetrics and Gynecology, Kasr Alainy Hospital, Cairo University, Cairo, Egypt
,
Ameer A. AbdAllah
2   Department of Obstetrics and Gynecology, Minia University, Minia, Egypt
,
Sherif Dahab
1   Department of Obstetrics and Gynecology, Kasr Alainy Hospital, Cairo University, Cairo, Egypt
,
Mohamed Darwish
3   Department of Gynecology and Obstetrics, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt
,
Yahia Z. Ali
4   Department of Gynecology and Obstetrics, Faculty of Medicine, Fayoum University, Fayoum, Egypt
,
Haitham Badran
4   Department of Gynecology and Obstetrics, Faculty of Medicine, Fayoum University, Fayoum, Egypt
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Erratum: The Effect of Antenatal Vaginal Progesterone Administration on Uterine, Umbilical, and Fetal Middle Cerebral Artery Doppler Flow: A Cohort StudyAm J Perinatol 2020; 37(05): e1-e2
DOI: 10.1055/s-0042-1756680

Abstract

Objective This study aimed to evaluate the effect of vaginal progesterone (P) administration during the second and third trimesters of pregnancy on Doppler velocimetry of uterine, umbilical, and middle cerebral vessels.

Study Design A prospective cohort study conducted on 80 women at risk for preterm labor. Uterine artery, umbilical artery, and middle cerebral artery (MCA) Doppler indices were measured before and after 1 week of administration of 200 mg twice daily vaginal P. The primary outcome parameter was the change of MCA pulsatility index (PI) after P administration. Secondary outcomes included changes in uterine artery and umbilical artery Doppler measurement.

Results There was no significant changes of umbilical artery resistance index (RI) (0.69 ± 0.049 vs. 0.68 ± 0.041), umbilical artery PI (1.14 ± 0.118 vs. 1.11 ± 0.116), uterine artery RI (0.66 ± 0.12 vs. 0.66 ± 0.107), uterine artery PI (1.00 ± 0.26 vs. 1.016 ± 0.24), and MCA PI (1.27 ± 0.18 vs. 1.26 ± 0.23) measurements before and after 1 week of P administration, respectively.

Conclusion Administration of vaginal P has no significant effects on uterine artery, umbilical artery, and MCA Doppler indices.

Keywords

progesterone - preterm birth - umbilical artery Doppler - uterine artery Doppler - middle cerebral artery Doppler

Authors' Contributions

A.M.M.: Project development and revision of the article. A.Y.S.: Project development and revision of data. E.A.H.: Project development, data collection, and revision of the article. A.A.: Review of literature, data collection, and article writing. D.S.E.: Review of literature, data analysis, and article writing. A.E.: Article writing. S.D.: Article writing. M.D.: Data reanalysis and revision of the article. Y.Z.: Data reanalysis and revision of the article. H.B.: Data reanalysis and revision of the article.


Note

Informed consent was obtained from all individual participants included in the study.


Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. We obtained Kasr Alainy local ethical committee approval.


Note

Clinical trial registration number is ClinicalTrials.gov IDNCT03292939.




Publication History

Received: 29 December 2018

Accepted: 05 February 2019

Publication Date:
13 March 2019 (online)

© 2019. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
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Comment to this article:

Comment: The Effect of Antenatal Vaginal Progesterone Administration on Uterine, Umbilical, and Fetal Middle Cerebral Artery Doppler Flow: A Cohort StudyAm J Perinatol 2024; 41(03): 373-374
DOI: 10.1055/a-1787-7744

 

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