Synlett 2019; 30(19): 2107-2112
DOI: 10.1055/s-0039-1690225
synpacts
© Georg Thieme Verlag Stuttgart · New York

Iridium-Catalyzed Asymmetric C–H Borylation Enabled by Chiral Bidentate Boryl Ligands

Yongjia Shi
a  State Key Laboratory for Oxo Synthesis and Selective Oxidation, Center for Excellence in Molecular Synthesis, Suzhou Research Institute, Lanzhou Institute of Chemical Physics, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Lanzhou 73000, P. R. of China   Email: senmiaoxu@licp.cas.cn
b  University of Chinese Academy of Sciences, Beijing 100049, P. R. of China
,
Qian Gao
a  State Key Laboratory for Oxo Synthesis and Selective Oxidation, Center for Excellence in Molecular Synthesis, Suzhou Research Institute, Lanzhou Institute of Chemical Physics, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Lanzhou 73000, P. R. of China   Email: senmiaoxu@licp.cas.cn
,
Senmiao Xu
a  State Key Laboratory for Oxo Synthesis and Selective Oxidation, Center for Excellence in Molecular Synthesis, Suzhou Research Institute, Lanzhou Institute of Chemical Physics, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Lanzhou 73000, P. R. of China   Email: senmiaoxu@licp.cas.cn
c  Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou 311121, P. R. of China
› Author Affiliations
We thank the National Natural Science Foundation of China (Grant numbers 21573262 and 21801246) and the Natural Science Foundation of Jiangsu Province (Grant numbers BK20161259 and BK20170422) for generous financial support.
Further Information

Publication History

Received: 15 August 2019

Accepted after revision: 10 October 2019

Publication Date:
28 October 2019 (online)

Abstract

Asymmetric synthesis of optically pure organoboron compounds is a topic that has received a number of attentions owing to their particular importance in synthetic chemistry and drug discovery. We herein highlight recent advances in the iridium-catalyzed C–H borylation of diarylmethylamines and cyclopropanes enabled by chiral bidentate boryl ligands.

1 Introduction

2 Ir-Catalyzed Asymmetric C(sp2)–H Borylation of Diarylmethylamines

3 Ir-Catalyzed Enantioselective C(sp3)–H Borylation of Cyclopropanes

4 Conclusion

 
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