Am J Perinatol 2020; 37(09): 929-932
DOI: 10.1055/s-0039-1691746
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Effect of Neonatal Phototherapy on Eosinophil Levels in Nonsevere Hyperbilirubinemia

Ceren Can
1  Department of Pediatric Immunology and Allergy, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey
Şahin Hamilcıkan
2  Department of Pediatrics, Bagcılar Training and Research Hospital, Istanbul, Turkey
› Author Affiliations
Further Information

Publication History

06 February 2019

18 April 2019

Publication Date:
24 May 2019 (online)


Objective The purpose of the research was to determine the impact of phototherapy (PT) on eosinophil levels in neonates with nonsevere bilirubin levels (<20 mg/dL) treated with PT.

Study Design This observational pilot study included term neonates with early neonatal hyperbilirubinemia.

Results Ninety-six term neonates were included in the study. The male-to-female ratio was 1.23. Hyperbilirubinemia was most frequently related to ABO group incompatibility (49%). Fifty-two neonates (54.1%) were born by normal spontaneous delivery. After PT, while total serum bilirubin, hemoglobin, hematocrit, leukocyte, and neutrophil levels were found to be significantly decreased, eosinophil levels were significantly increased (p = 0.01). No significant difference was found regarding lymphocyte and basophil levels after PT. A statistically significant correlation was found between bilirubin and eosinophil levels before PT (r 2 = 0.28, p = 0.03). No correlation between eosinophil levels and treatment age, gender, diagnosis of hyperbilirubinemia, and delivery route before PT was found. After PT, eosinophil levels increased, while other blood cell series were found to be decreased. The correlation between the bilirubin levels and eosinophil was found to be negative (r 2 = − 0.32, p = 0.02) after PT.

Conclusion PT may increase serum eosinophil levels in term neonates with nonsevere hyperbilirubinemia.