Am J Perinatol 2019; 36(S 02): S29-S32
DOI: 10.1055/s-0039-1691797
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Neonatal Resuscitation: State of the Art

Daniele Trevisanuto
1   Department of Woman's and Child's Health, University of Padova, Padova, Italy
,
Alfonso Galderisi
1   Department of Woman's and Child's Health, University of Padova, Padova, Italy
› Author Affiliations
Further Information

Publication History

Publication Date:
25 June 2019 (online)

Abstract

The objective of this study is to revise novel evidence and forthcoming clinical trials that focused on the gap of knowledge raised during the 2015 guidelines for neonatal resuscitation. Literature search on main topics on neonatal resuscitation published after 2015 edition of the consensus on science and guidelines was performed. Only relevant articles (mainly randomized controlled trials [RCTs] and meta-analyses) were included and presented as descriptive review. In the past years, new RCTs and/or meta-analyses have become available on umbilical cord clamping and umbilical cord milking, oxygen concentrations to start resuscitation in term and preterm infants, use of laryngeal mask, sustained lung inflation, less invasive surfactant administration, and heart rate assessment. Despite the increasing available literature on neonatal resuscitation in the past years, many interventions are still performed without robust scientific evidence. Adequately powered and well-designed RCTs are needed to optimize management of neonates at birth.

 
  • References

  • 1 Perlman JM, Wyllie J, Kattwinkel J. , et al; Neonatal Resuscitation Chapter Collaborators. Part 7: Neonatal Resuscitation: 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation 2015; 132 (16) (Suppl. 01) S204-S241
  • 2 Wyckoff MH, Aziz K, Escobedo MB. , et al. Part 13: Neonatal Resuscitation: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2015; 132 (18) (Suppl. 02) S543-S560
  • 3 Wyllie J, Bruinenberg J, Roehr CC, Rüdiger M, Trevisanuto D, Urlesberger B. European Resuscitation Council Guidelines for Resuscitation 2015: Section 7. Resuscitation and support of transition of babies at birth. Resuscitation 2015; 95: 249-263
  • 4 Katheria A, Garey D, Truong G. , et al. A randomized clinical trial of umbilical cord milking vs delayed cord clamping in preterm infants: neurodevelopmental outcomes at 22-26 months of corrected age. J Pediatr 2018; 194: 76-80
  • 5 Andersson O, Lindquist B, Lindgren M, Stjernqvist K, Domellöf M, Hellström-Westas L. Effect of delayed cord clamping on neurodevelopment at 4 years of age: a randomized clinical trial. JAMA Pediatr 2015; 169 (07) 631-638
  • 6 Fogarty M, Osborn DA, Askie L. , et al. Delayed vs early umbilical cord clamping for preterm infants: a systematic review and meta-analysis. Am J Obstet Gynecol 2018; 218 (01) 1-18
  • 7 Katheria AC, Brown MK, Faksh A. , et al. Delayed cord clamping in newborns born at term at risk for resuscitation: a feasibility randomized clinical trial. J Pediatr 2017; 187: 313-317
  • 8 Trevisanuto D, Testoni D, de Almeida MFB. Maintaining normothermia: why and how?. Semin Fetal Neonatal Med 2018; 23 (05) 333-339
  • 9 Mullany LC, Katz J, Khatry SK, LeClerq SC, Darmstadt GL, Tielsch JM. Risk of mortality associated with neonatal hypothermia in southern Nepal. Arch Pediatr Adolesc Med 2010; 164 (07) 650-656
  • 10 Laptook AR, Salhab W, Bhaskar B. ; Neonatal Research Network. Admission temperature of low birth weight infants: predictors and associated morbidities. Pediatrics 2007; 119 (03) e643-e649
  • 11 Lyu Y, Shah PS, Ye XY. , et al; Canadian Neonatal Network. Association between admission temperature and mortality and major morbidity in preterm infants born at fewer than 33 weeks’ gestation. JAMA Pediatr 2015; 169 (04) e150277
  • 12 Perlman SB, Huppert TJ, Luna B. Functional near-infrared spectroscopy evidence for development of prefrontal engagement in working memory in early through middle childhood. Cereb Cortex 2016; 26 (06) 2790-2799
  • 13 Welsford M, Nishiyama C, Shortt C. , et al; International Liaison Committee on Resuscitation Neonatal Life Support Task Force. Room air for initiating term newborn resuscitation: a systematic review with meta-analysis. Pediatrics 2019; 143 (01) e20181825
  • 14 Escobedo MB, Shah BA, Song C, Makkar A, Szyld E. Recent recommendations and emerging science in neonatal resuscitation. Pediatr Clin North Am 2019; 66 (02) 309-320
  • 15 Qureshi MJ, Kumar M. Laryngeal mask airway versus bag-mask ventilation or endotracheal intubation for neonatal resuscitation. Cochrane Database Syst Rev 2018; 3: CD003314
  • 16 Foglia EE, Nolen TL, DeMauro SB. , et al; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Short-term outcomes of infants enrolled in randomized clinical trials vs those eligible but not enrolled. JAMA 2015; 313 (23) 2377-2379
  • 17 Kirpalani H, Ratcliffe SJ, Keszler M. , et al; SAIL Site Investigators. Effect of sustained inflations vs intermittent positive pressure ventilation on bronchopulmonary dysplasia or death among extremely preterm infants: the SAIL randomized clinical trial. JAMA 2019; 321 (12) 1165-1175
  • 18 Isayama T, Iwami H, McDonald S, Beyene J. Association of noninvasive ventilation strategies with mortality and bronchopulmonary dysplasia among preterm infants: a systematic review and meta-analysis. JAMA 2016; 316 (06) 611-624
  • 19 Aldana-Aguirre JC, Pinto M, Featherstone RM, Kumar M. Less invasive surfactant administration versus intubation for surfactant delivery in preterm infants with respiratory distress syndrome: a systematic review and meta-analysis. Arch Dis Child Fetal Neonatal Ed 2017; 102 (01) F17-F23
  • 20 Binotti M, Cavallin F, Ingrassia PL. , et al. Heart rate assessment using NeoTapAdvancedSupport: a simulation study. Arch Dis Child Fetal Neonatal Ed 2018 . Doi: 10.1136/archdischild-2018-315408