Neonatal Jaundice: The Other Side of the Coin in the Development of Allergy
Objective The current study aims to assess the association between different characteristics of neonatal jaundice and common types of allergic diseases in childhood (as bronchial asthma, acute urticaria, and allergic rhinitis).
Study Design A case-control study is conducted on 300 allergic children and 300 healthy children as a control group at Fayoum University Hospital. The study was conducted over a span of 2 years, from May 2016 to May 2018. Bronchial asthma, allergic rhinitis, and acute urticaria diagnoses were based on physician clinical examination using specific guidelines for each. For the data regarding children's demographic and maternal characteristics, a structured questionnaire was used. Regarding neonatal jaundice, data were collected from the patients' hospital records.
Results Children with neonatal jaundice are more likely to develop allergy with 57% higher than neonates without jaundice. Early onset jaundice and treatment by phototherapy have statistically significant association with the development of allergic diseases.
Conclusion Different aspects of neonatal jaundice are associated with the development of common allergic diseases in children.
H.S. designed the study and contributed to data collection. H.S. and A.Y.E. wrote the manuscript. A.Y.E. performed the statistical analysis and interpretation of the results. Both authors have read and approved the final manuscript.
Received: 14 November 2018
Accepted: 13 June 2019
31 July 2019 (online)
© 2020. Thieme. All rights reserved.
Thieme Medical Publishers
333 Seventh Avenue, New York, NY 10001, USA.
- 1 Pawankar R, Canonica GW, . ST Holgate ST, Lockey RF, Blaiss MS. , eds. WAO White Book on Allergy. Milwaukee, WI: World Allergy Organization; 2013
- 2 Pawankar R. Allergic diseases and asthma: a global public health concern and a call to action. World Allergy Organ J 2014; 7 (01) 12
- 3 Gupta R, Sheikh A, Strachan DP, Anderson HR. Burden of allergic disease in the UK: secondary analyses of national databases. Clin Exp Allergy 2004; 34 (04) 520-526
- 4 WHO. Asthma: key facts. Available at: https://www.who.int/news-room/fact-sheets/detail/asthma . Accessed April, 2017
- 5 Huang L, Bao Y, Xu Z. et al. Neonatal bilirubin levels and childhood asthma in the US Collaborative Perinatal Project, 1959-1965. Am J Epidemiol 2013; 178 (12) 1691-1697
- 6 Gloria-Bottini F, Bottini E. Is there a role of early neonatal events in susceptibility to allergy?. Int J Biomed Sci 2010; 6 (01) 8-12
- 7 Cohen SM. Jaundice in the full-term newborn. Pediatr Nurs 2006; 32 (03) 202-208
- 8 Nadeem A, Masood A, Siddiqui N. Oxidant--antioxidant imbalance in asthma: scientific evidence, epidemiological data and possible therapeutic options. Ther Adv Respir Dis 2008; 2 (04) 215-235
- 9 Das RR, Naik SS. Neonatal hyperbilirubinemia and childhood allergic diseases: a systematic review. Pediatr Allergy Immunol 2015; 26 (01) 2-11
- 10 Procianoy RS, Silveira RC, Fonseca LT, Heidemann LA, Neto EC. The influence of phototherapy on serum cytokine concentrations in newborn infants. Am J Perinatol 2010; 27 (05) 375-379
- 11 Central Agency for Public Mobilization and Statistics. Demographic and Vital Statistics (Statistics of morbidities) estimation for the year. Statistical year book 2013, Cairo, Egypt. Central Agency for Public Mobilization and Statistics [Arab Republic of Egypt]; 2013. Available at: https://www.capmas.gov.eg/ . Accessed July 22, 2019
- 12 Egypt Human Development Reports. Human development indicators. Available at: http://hdr.undp.org/en/countries/profiles/EGY . Accessed April, 2017
- 13 Morosco G, Kiley J. National asthma education and prevention program, Expert Panel Report 3: Guidelines for the diagnosis and management of asthma. : Available at: https://www.nhlbi.nih.gov/files/docs/guidelines/asthsumm.pdf . Accessed April 2017
- 14 Scadding GK, Kariyawasam HH, Scadding G. et al. BSACI guideline for the diagnosis and management of allergic and non-allergic rhinitis. Clin Exp Allergy 2017; 47: 856-889
- 15 Grattan CEH, Humphreys F. British Association of Dermatologists Therapy Guidelines and Audit Subcommittee. Guidelines for evaluation and management of urticaria in adults and children. Br J Dermatol 2007; 157 (06) 1116-1123
- 16 Aspberg S, Dahlquist G, Kahan T, Källén B. Is neonatal phototherapy associated with an increased risk for hospitalized childhood bronchial asthma?. Pediatr Allergy Immunol 2007; 18 (04) 313-319
- 17 Aspberg S, Dahlquist G, Kahan T, Källén B. Confirmed association between neonatal phototherapy or neonatal icterus and risk of childhood asthma. Pediatr Allergy Immunol 2010; 21 (4, Pt. 2): e733-e739
- 18 Ku MS, Sun HL, Sheu JN, Lee HS, Yang SF, Lue KH. Neonatal jaundice is a risk factor for childhood asthma: a retrospective cohort study. Pediatr Allergy Immunol 2012; 23 (07) 623-628
- 19 Sun HL, Lue KH, Ku MS. Neonatal jaundice is a risk factor for childhood allergic rhinitis: a retrospective cohort study. Am J Rhinol Allergy 2013; 27 (03) 192-196
- 20 Wei CC, Lin CL, Shen TC, Kao CH. Neonatal jaundice and risks of childhood allergic diseases: a population-based cohort study. Pediatr Res 2015; 78 (02) 223-230
- 21 Piazza AJ, Stoll BJ, Kliegman RM. et al. Jaundice and hyperbilirubinemia in the newborn. In: Kliegman R. , St. Geme J. Nelson Textbook of Pediatrics. 18th ed. Philadelphia, PA: WB Saunders; 2007: 756-766
- 22 Sarici SU, Serdar MA, Korkmaz A. et al. Incidence, course, and prediction of hyperbilirubinemia in near-term and term newborns. Pediatrics 2004; 113 (04) 775-780
- 23 Kalliomäki M, Isolauri E. Role of intestinal flora in the development of allergy. Curr Opin Allergy Clin Immunol 2003; 3 (01) 15-20
- 24 Hsu SP, Lin KN, Tan CT, Lee FP, Huang HM. ; Szu-PinHsu. Prenatal risk factors and occurrence of allergic rhinitis among elementary school children in an urban city. Int J Pediatr Otorhinolaryngol 2009; 73 (06) 807-810
- 25 Metsälä J, Kilkkinen A, Kaila M. et al. Perinatal factors and the risk of asthma in childhood--a population-based register study in Finland. Am J Epidemiol 2008; 168 (02) 170-178