Am J Perinatol 2020; 37(02): 216-223
DOI: 10.1055/s-0039-1697672
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Relationship between Duration of Infant Exposure to a Moderate-to-Large Patent Ductus Arteriosus Shunt and the Risk of Developing Bronchopulmonary Dysplasia or Death Before 36 Weeks

Ronald I. Clyman
1  Department of Pediatrics, University of California San Francisco, San Francisco, California
2  Cardiovascular Research Institute, University of California San Francisco, San Francisco, California
,
Nancy K. Hills
3  Department of Neurology, University of California San Francisco, San Francisco, California
,
Melissa Liebowitz
1  Department of Pediatrics, University of California San Francisco, San Francisco, California
,
Sandy Johng
1  Department of Pediatrics, University of California San Francisco, San Francisco, California
› Author Affiliations
Funding This work was supported by a grant from the U.S. Public Health Service National Heart, Lung and Blood Institute (HL109199) and a gift from the Jamie and Bobby Gates Foundation.
Further Information

Publication History

24 May 2019

16 August 2019

Publication Date:
10 October 2019 (online)

Abstract

Objective This study was aimed to examine the relationship between duration of infant exposure to a moderate-to-large patent ductus arteriosus (PDA) shunt and the risk of developing bronchopulmonary dysplasia (BPD) or death before 36 weeks (BPD/death).

Study Design Infants <28 weeks' gestation who survived ≥7 days (n = 423) had echocardiograms performed on day 7 and at planned intervals.

Results In multivariable regression models, BPD/death did not appear to be increased until infants had been exposed to a moderate-to-large PDA for at least 7–13 days: OR (95%CI) (referent = closed or small PDA): moderate-to-large PDA exposure for <7 days: 0.38 (range, 0.10–1.46); for 7 to 13 days = 2.12 (range, 1.04–4.32); for ≥14 days = 3.86 (range, 2.15–6.96). Once the threshold of 7 to 13 days had been reached, additional exposure (≥14 days) did not significantly add to the increased incidence of BPD/death: (referent exposure = 7–13 days) exposure for 14 to 27 days = 1.34 (range, 0.52–3.45); for 28 to 48 days = 2.34 (range, 0.88–6.19); for ≥49 days = 1.80 (range. 0.59–5.47). A similar relationship was found for the outcome of BPD-alone.

Conclusion Infants < 28 weeks' gestation required at least 7 to 13 days of exposure to a moderate-to-large PDA before a significant increase in the incidence of BPD/death was apparent. Once this threshold was reached additional exposure to a moderate-to-large PDA did not significantly add to the increased incidence of BPD/death.