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Am J Perinatol 2021; 38(05): 456-462
DOI: 10.1055/s-0039-1698455
Original Article

Clinical Tolerance of In-Neonatal Intensive Care Unit Administration of Rotavirus Vaccine

Courtney Briggs-Steinberg
1   Division of Neonatology, Department of Pediatrics, Staten Island University Hospital, Northwell Health, Staten Island, New York
2   Department of Pediatrics, Zucker School of Medicine at Hofstra/Northwell, Staten Island, New York
,
David Aboudi
3   Division of Newborn Medicine, Department of Pediatrics, Maria Fareri Children's Hospital at Westchester Medical Center, New York Medical College, Valhalla, New York
,
Gabrielle Hodson
4   Department of Pharmacy, Maria Fareri Children's Hospital at Westchester Medical Center, New York Medical College, Valhalla, New York
,
Shetal Shah
3   Division of Newborn Medicine, Department of Pediatrics, Maria Fareri Children's Hospital at Westchester Medical Center, New York Medical College, Valhalla, New York
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Abstract

Objective This article determines the tolerance of neonatal intensive care unit (NICU)-based administration of RV5 in premature infants. This article also aims to compare the rate of clinically significant adverse events after RV5 immunization to the standard 2-month shot series and to historical controls who were not immunized.

Study Design This is a retrospective case–control study of 201 premature infants immunized with RV5. Infants were evaluated for clinically significant events 7 days before and after immunization and were compared with events after the 2-month shot series and to 189 historical controls. Wilcoxon signed rank test and McNemar's test were used for all paired analysis.

Results There was no increase in number of infants with clinically significant adverse events when comparing after RV5 to prior to RV5, after the 2-month shot series, or to the historical controls.

Conclusion RV5 is well tolerated in premature infants and does not result in clinically significant adverse events when administered in NICU-hospitalized infants.

Keywords

rotavirus - neonatal intensive care unit - premature - immunization


Publication History

Received: 23 May 2019

Accepted: 29 August 2019

Article published online:
18 November 2019

© 2019. Thieme. All rights reserved.

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