Journal of Pediatric Epilepsy
DOI: 10.1055/s-0040-1713153
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Neuroglobin and Prolactin As Potential Biomarkers for Differentiating Epileptic versus Nonepileptic Paroxysmal Disorders in Children

Mohammed Hashem Mahgoob
1  Department of Pediatrics, Faculty of Medicine, Minia University, Minia, Egypt
Mahmoud Mohammed Moussa
2  Department of Clinical Pathology, Faculty of Medicine, Minia University, Minia, Egypt
› Author Affiliations
Funding None.
Further Information

Publication History

Publication Date:
19 June 2020 (online)


At least 20% of patients referred to pediatric epilepsy centers with the suspicion of epileptic seizures actually have other conditions. Neuroglobin is a new globin member which is highly expressed in the central and peripheral nervous systems. We aim to evaluate usefulness of neuroglobin to differentiate between epilepsy and other conditions that mimic epilepsy. Our study was conducted on 90 children divided into three groups: 30 patients with epileptic seizures, 35 children with nonepileptic paroxysmal disorder, and 25 apparently healthy, age and sex-matched children as a normal control. Complete blood count, blood chemistries including random blood glucose, calcium, sodium, in addition to serum prolactin, and neuroglobin were performed for all children. The study showed a significant increase of both serum neuroglobin and prolactin levels in epileptic group compared with nonepileptic paroxysmal disorder and control groups (p < 0.01). Serum neuroglobin showed 95% sensitivity and 95.7% specificity in the diagnosis of generalized seizures. Serum neuroglobin may be a promising novel marker to differentiate epileptic versus nonepileptic disorders in children in the emergency setting, when history and clinical presentation are equivocal.


Further studies may be performed with more sample size, serial measurements of serum neuroglobin, and prolactin to know the time peak of both of them.

Original Article

Not under submission or consideration for publication in any other journal.