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J Pediatr Intensive Care 2022; 11(01): 067-071
DOI: 10.1055/s-0040-1714707
Case Report

Suspected Case of Drug-Induced Acute Respiratory Distress Syndrome following Trimethoprim-Sulfamethoxazole Treatment

Julia Natterer
1   Pediatric Intensive Care Unit, Women, Mothers and Children's Department, Faculty of Medicine and Biology, Lausanne University Hospital, Lausanne, Switzerland
,
Frida Rizzati
1   Pediatric Intensive Care Unit, Women, Mothers and Children's Department, Faculty of Medicine and Biology, Lausanne University Hospital, Lausanne, Switzerland
,
Marie-Hélène Perez
1   Pediatric Intensive Care Unit, Women, Mothers and Children's Department, Faculty of Medicine and Biology, Lausanne University Hospital, Lausanne, Switzerland
,
David Longchamp
1   Pediatric Intensive Care Unit, Women, Mothers and Children's Department, Faculty of Medicine and Biology, Lausanne University Hospital, Lausanne, Switzerland
,
Vivianne Amiet
1   Pediatric Intensive Care Unit, Women, Mothers and Children's Department, Faculty of Medicine and Biology, Lausanne University Hospital, Lausanne, Switzerland
,
Quentin DeHalleux
2   Pediatric Physiotherapy Unit, Women, Mothers and Children's Department, Faculty of Medicine and Biology, Lausanne University Hospital, Lausanne, Switzerland
,
Kim Dao
3   Service of Clinical Pharmacology, Department of Laboratories Medicine and Pathology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland
,
Thomas Ferry
1   Pediatric Intensive Care Unit, Women, Mothers and Children's Department, Faculty of Medicine and Biology, Lausanne University Hospital, Lausanne, Switzerland
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Abstract

In this article, we reported the case of a child patient who was admitted to our PICU for severe acute respiratory distress syndrome (ARDS) while being treated with trimethoprim-sulfamethoxazole (TMP-SMX) for osteomyelitis. Based on the timing of exposure, lack of alternative explanations, and clinical course similar to previously described cases, we suspect that TMP-SMX may have triggered ARDS. Despite meeting criteria for extracorporeal membrane oxygenation cannulation, conservative management and lung recruitment with high-frequency percussive ventilation could avoid the latter.

Keywords

acute respiratory distress syndrome - trimethoprim - percussive ventilation


Publication History

Received: 23 March 2020

Accepted: 11 June 2020

Article published online:
30 July 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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