Download PDF
J Pediatr Infect Dis 2021; 16(03): 129-133
DOI: 10.1055/s-0041-1724024
Original Article

Diagnostic Value of Plasma Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Children with Urinary Tract Infections

Serkan Tursun
1   Department of Pediatrics, School of Medicine, Kirikkale University, Kirikkale, Turkey
,
Ayşegül Alpcan
1   Department of Pediatrics, School of Medicine, Kirikkale University, Kirikkale, Turkey
,
Metin Özsoy
2   Department of Infectious Disease and Clinical Microbiology, Ankara Training and Research, Hospital Ankara, Turkey
,
Nermin Dindar Badem
3   Department of Medical Biochemistry, Gülhane Training and Research Hospital, Ankara, Turkey
,
Yaşar Kandur
1   Department of Pediatrics, School of Medicine, Kirikkale University, Kirikkale, Turkey
,
Banu Çelikel Acar
4   Department of Pediatric Nephrology, School of Medicine, Ankara City Hospital, University of Health Sciences, Ankara, Turkey
› Author Affiliations Funding None.
› Further Information
    Permissions and Reprints

Abstract

Objective The aim of the present study was to evaluate the diagnostic value of soluble triggering receptor on myeloid cells-1 as a novel marker for diagnosis of childhood urinary tract infections (UTI).

Methods This study enrolled 30 pediatric patients diagnosed with acute febrile UTIs; 30 healthy children were included as the control group. The blood samples from the patients and healthy controls were collected for a soluble triggering receptor on myeloid cells-1 (sTREM-1) test.

Results The study group was composed of 9 males and 21 females, and the mean age of the study population was 6.6 ± 3.2 (range = 1–14) years. sTREM-1 levels were significantly higher in UTI patients than in the controls (592 ± 323 vs. 490 ± 299 pg/mL, p = 0.04). The receiver operating curve analysis revealed a cut-off value of soluble triggering receptor expressed on myeloid cells-1 of 514 ng/mL (area under the curve = 0.562). When the cut-off value was taken 514 pg/mL, soluble triggering receptor expressed on myeloid cells-1 had a sensitivity of 57% and a specificity of 50% for the diagnosis of UTI.

Conclusion The present study revealed that plasma sTREM-1 level may be elevated in UTI and may therefore serve as a useful predictive tool for the diagnosis of UTI.

Keywords

urinary tract infections - biomarker - myeloid cells-1

Authors' Contributions

S.T., A.A., M.O., N.D.B., and B.C.A. contributed in the completion of this document and attest to its validity on behalf of the co-authors.




Publication History

Received: 01 August 2020

Accepted: 13 January 2021

Article published online:
25 February 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Elder JS. Urologic disorders in infants and children. In: Behrman RE, Kliegman RM, Jenson HB. eds. Nelson Textbook of Pediatrics. 20th ed.. Philadelphia: WB Saunders; 2016: 2556
    Google Scholar
  • 2 Shaikh N, Morone NE, Bost JE, Farrell MH. Prevalence of urinary tract infection in childhood: a meta-analysis. Pediatr Infect Dis J 2008; 27 (04) 302-308
    CrossrefPubMedGoogle Scholar
  • 3 Hay AD, Sterne JAC, Hood K. et al. Improving the diagnosis and treatment of urinary tract infection in young children in primary care: results from the DUTY prospective diagnostic cohort study. Ann Fam Med 2016; 14 (04) 325-336
    CrossrefPubMedGoogle Scholar
  • 4 Roberts KB, Downs SM, Finnell SME. et al; Subcommittee on Urinary Tract Infection, Steering Committee on Quality Improvement and Management. Urinary tract infection: clinical practice guideline for the diagnosis and management of the initial UTI in febrile infants and children 2 to 24 months. Pediatrics 2011; 128 (03) 595-610
    CrossrefPubMedGoogle Scholar
  • 5 Lubell TR, Barasch JM, Xu K, Ieni M, Cabrera KI, Dayan PS. Urinary neutrophil gelatinase-associated lipocalin for the diagnosis of urinary tract infections. Pediatrics 2017; 140 (06) e20171090
    CrossrefPubMedGoogle Scholar
  • 6 Miao Y, Liu Z-J, Gong J-P, Wei SD, Xu FL, Chen ZZ. [Expression of human triggering receptor expressed on myeloid cells 1 in peripheral blood mononuclear cells of patients with acute obstructive suppurative cholangitis]. Nan Fang Yi Ke Da Xue Xue Bao 2009; 29 (11) 2179-2181
    PubMedGoogle Scholar
  • 7 Kim MH, Lim G, Kang SY, Lee WI, Suh JT, Lee HJ. Utility of procalcitonin as an early diagnostic marker of bacteremia in patients with acute fever. Yonsei Med J 2011; 52 (02) 276-281
    CrossrefPubMedGoogle Scholar
  • 8 Cifci A, Durmaz Ceylan S, Oklu K. et al. A new inflammatory marker in overweight patients: triggering receptor expressed on myeloid cells-1. Bratisl Lek Listy 2020; 121 (04) 259-262
    PubMedGoogle Scholar
  • 9 Sosinsky LS, Gilliam WS. Childcare: how pediatricians can support children and families. In: Behrman RE, Kliegman RM, Jenson HB. eds. Nelson Textbook of Pediatrics. 20th ed.. Philadelphia: WB Saunders; 2016: 103
    Google Scholar
  • 10 American Academy of Pediatrics. Committee on Quality Improvement. Subcommittee on Urinary Tract Infection. Practice parameter: the diagnosis, treatment, and evaluation of the initial urinary tract infection in febrile infants and young children. Pediatrics 1999; 103 (4 Pt 1): 843-852
    CrossrefPubMedGoogle Scholar
  • 11 SUBCOMMITTEE ON URINARY TRACT INFECTION. Reaffirmation of AAP clinical practice guideline: the diagnosis and management of the initial urinary tract infection in febrile infants and young children 2–24 months of age. Pediatrics 2016; 138 (06) e20163026
    CrossrefPubMedGoogle Scholar
  • 12 Pontrelli G, De Crescenzo F, Buzzetti R. et al. Diagnostic value of soluble triggering receptor expressed on myeloid cells in paediatric sepsis: a systematic review. Ital J Pediatr 2016; 42: 44
    CrossrefPubMedGoogle Scholar
  • 13 Saldir M, Tunc T, Cekmez F. et al. Endocan and soluble triggering receptor expressed on myeloid cells-1 as novel markers for neonatal sepsis. Pediatr Neonatol 2015; 56 (06) 415-421
    CrossrefPubMedGoogle Scholar
  • 14 Arízaga-Ballesteros V, Alcorta-García MR, Lázaro-Martínez LC. et al. Can sTREM-1 predict septic shock & death in late-onset neonatal sepsis? A pilot study. Int J Infect Dis 2015; 30: 27-32
    CrossrefPubMedGoogle Scholar
  • 15 Adly AAM, Ismail EA, Andrawes NG, El-Saadany MA. Circulating soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) as diagnostic and prognostic marker in neonatal sepsis. Cytokine 2014; 65 (02) 184-191
    CrossrefPubMedGoogle Scholar
  • 16 Ozdemir SA, Colak R, Ergon EY, Calkavur S. Diagnostic value of urine strem-1 and urine c-reactive protein for infants with late onset neonatal sepsis. J Pediatr Infect Dis 2020; 15: 72-78
    Article in Thieme ConnectPubMedGoogle Scholar
  • 17 Gibot S, Cravoisy A, Kolopp-Sarda M-N. et al. Time-course of sTREM (soluble triggering receptor expressed on myeloid cells)-1, procalcitonin, and C-reactive protein plasma concentrations during sepsis. Crit Care Med 2005; 33 (04) 792-796
    CrossrefPubMedGoogle Scholar
  • 18 Ravetti CG, Moura AD, Vieira ÉL, Pedroso ERP, Teixeira AL. sTREM-1 predicts intensive care unit and 28-day mortality in cancer patients with severe sepsis and septic shock. J Crit Care 2015; 30 (02) 440.e7-440.e13
    CrossrefPubMedGoogle Scholar
  • 19 Cao C, Gu J, Zhang J. Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis of infectious diseases. Front Med 2017; 11 (02) 169-177
    CrossrefPubMedGoogle Scholar
  • 20 Gibot S, Cravoisy A. Soluble form of the triggering receptor expressed on myeloid cells-1 as a marker of microbial infection. Clin Med Res 2004; 2 (03) 181-187
    CrossrefPubMedGoogle Scholar
  • 21 Zhang J, She D, Feng D, Jia Y, Xie L. Dynamic changes of serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) reflect sepsis severity and can predict prognosis: a prospective study. BMC Infect Dis 2011; 11: 53
    CrossrefPubMedGoogle Scholar
  • 22 Su Lxiang, Feng L, Zhang J. et al. Diagnostic value of urine sTREM-1 for sepsis and relevant acute kidney injuries: a prospective study. Crit Care 2011; 15: R250
    CrossrefPubMedGoogle Scholar
  • 23 Allan GM, Young J. Complete blood count for screening?. Can Fam Physician 2017; 63 (10) 772
    PubMedGoogle Scholar
  • 24 Bali R, Sharma P, Ghanghas P. et al. To compare the efficacy of C-reactive protein and total leucocyte count as markers for monitoring the course of odontogenic space infections. J Maxillofac Oral Surg 2017; 16 (03) 322-327
    CrossrefPubMedGoogle Scholar
  • 25 Sierra-Diaz E, Bravo Cuéllar A, Ortiz Lazareno PC, García Gutiérrez M, Georgina HF, Anaya Prado R. Urine TREM-1 as a marker of urinary tract infection in children. J Int Med Res 2017; 45 (02) 631-638
    CrossrefPubMedGoogle Scholar
  • 26 Gibot S, Béné MC, Noel R. et al. Combination biomarkers to diagnose sepsis in the critically ill patient. Am J Respir Crit Care Med 2012; 186 (01) 65-71
    CrossrefPubMedGoogle Scholar