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CC BY 4.0 · Journal of Child Science 2021; 11(01): e120-e124
DOI: 10.1055/s-0041-1731076
Original Article

Vitamin D Status in Children with Idiopathic Dilated Cardiomyopathy

Duaa M. Raafat
1   Department of Pediatrics, Children's Hospital, Faculty of Medicine, Assiut University, Assiut, Egypt
,
Osama M. EL-Asheer 
1   Department of Pediatrics, Children's Hospital, Faculty of Medicine, Assiut University, Assiut, Egypt
,
Amal A. Mahmoud
2   Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt
,
Manal M. Darwish 
3   Department of Public Health and Community Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt
,
Naglaa S. Osman
1   Department of Pediatrics, Children's Hospital, Faculty of Medicine, Assiut University, Assiut, Egypt
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Abstract

Dilated cardiomyopathy (DCM) is the third leading cause of heart failure in pediatrics. The exact etiology of DCM is unknown in more than half of the cases. Vitamin D receptors are represented in cardiac muscles, endothelium, and smooth muscles of blood vessels suggesting that vitamin D could have a vital cardioprotective function. This study aimed to assess serum level of vitamin D in children with idiopathic DCM and to correlate the serum level of vitamin D with the left ventricular dimensions and function. This study is a descriptive cross-sectional single-center study, includes 44 children of both sexes, diagnosed as idiopathic DCM. Serum level of vitamin D was assessed and correlated with the left ventricular dimensions and function. Mean age of studied children was 6.08 ± 4.4 years. Vitamin D deficiency was found in 90.9% of children with idiopathic DCM with a mean level 13.48 ng/mL. There was a negative correlation between vitamin D level and fraction shortening and left ventricular end-diastolic diameter in children with DCM. Vitamin D level is not only significantly low in children with idiopathic DCM but it is also significantly correlated with the degree of left ventricular dysfunction.

Keywords

vitamin D - children - dilated cardiomyopathy

Ethical Approval

The study was approved by the ethics committee of the Faculty of Medicine, Assiut University (IRB no: 17300487). Written informed consents were taken from parents with explanation of benefits of the study; risks expected and suggested treatment for each case.


Authors' Contributions

All authors read and approved the final manuscript. O.E.-A, N.O., and D.R. designed the study, literature search, interpreted the data, and wrote the manuscript. D.R. did echocardiography for all studied cases. M.D. did statistical analysis, share in literature search and writing. A.M. did all laboratory work in addition to interpretation of data.




Publication History

Received: 01 January 2021

Accepted: 07 April 2021

Article published online:
19 June 2021

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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