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Effect of Endotracheal Suctioning on Infants Born through Meconium-Stained Amniotic Fluid: A Meta-AnalysisFunding None.
Objective Meconium is a common finding in amniotic fluid and placental specimens, particularly in term and post-term pregnancies. The objective of this paper was to perform a meta-analysis to examine the impact of endotracheal suctioning on the occurrence of meconium aspiration syndrome (MAS), mortality, and complications.
Study Design PubMed, EMBASE, and the Cochrane library were systematically searched for comparative studies. Odds ratios (ORs), weighted mean differences (WMDs), and corresponding 95% confidence intervals (CIs) were used to compare the outcomes.
Results Twelve studies were included in the meta-analysis. There were no significant impacts of endotracheal suctioning on the occurrence of MAS (OR = 3.05, 95% CI: 0.48–19.56), mortality (OR = 1.25, 95% CI: 0.35–4.44), the need for mechanical ventilation (OR = 4.20, 95% CI: 0.32–54.72), the occurrence of pneumothorax (OR = 0.99, 95% CI: 0.34–2.85), persistent pulmonary hypertension of the newborn (PPHN), (OR = 1.31, 95% CI: 0.58–2.98), hypoxic-ischemic encephalopathy (HIE) (OR = 0.82, 95% CI: 0.52–1.30), and length of stay (WMD = −0.11, 95% CI: −0.99–0.77).
Conclusion Routine endotracheal suctioning at birth is not useful in preventing MAS, mortality, mechanical ventilation, PPHN, HIE, and prolonged length of stay in neonates born through MSAF.
Routine suctioning is not recommended for newborns.
Endotracheal aspiration is not beneficial for MAS.
Future research may focus on selected neonates.
Data Availability Statement
The data used to support the findings of this study are available from the corresponding author upon request.
Q.W. substantially contributed to the conception or design, acquisition, analysis, and interpretation of data. WC contributed to acquisition, analysis, interpretation of data, and drafted the manuscript for important content. QL critically revised the manuscript for important intellectual content. SS gave final approval. JL contributed to acquisition, analysis, and interpretation of data.
¶ These authors contributed equally to this work.
Received: 07 September 2021
Accepted: 29 November 2021
11 January 2022 (online)
© 2022. Thieme. All rights reserved.
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