CC BY 4.0 · Surg J (N Y) 2022; 08(03): e174-e178
DOI: 10.1055/s-0042-1744152
Case Report

Primary Cervical Carcinosarcoma: Report of a Rare Case

1   Department of Obstetrics and Gynecology, Democritus University of Thrace, Dragana, Alexandroupolis, Greece
,
Zacharias Fasoulakis
2   Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, General Hospital of Athens “ALEXANDRA,” Athens, Greece
,
Antonios Koutras
2   Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, General Hospital of Athens “ALEXANDRA,” Athens, Greece
,
Thomas Ntounis
2   Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, General Hospital of Athens “ALEXANDRA,” Athens, Greece
,
Athina A. Samara
3   Department of Surgery, University Hospital of Larissa, Larissa, Greece
,
Athanasios Syllaios
4   Department of Surgery, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
,
Alexandros Diamantis
3   Department of Surgery, University Hospital of Larissa, Larissa, Greece
,
Maria Kouroupi
5   Department of Pathology, Democritus University of Thrace, Dragana, Alexandroupolis, Greece
,
Charilaos Stamos
5   Department of Pathology, Democritus University of Thrace, Dragana, Alexandroupolis, Greece
,
Emmanuel N. Kontomanolis
1   Department of Obstetrics and Gynecology, Democritus University of Thrace, Dragana, Alexandroupolis, Greece
› Author Affiliations
Funding None.

Abstract

Background Carcinosarcomas are malignant mixed Müllerian tumors (MMMT), containing both epithelial and mesenchymal components. Carcinosarcomas of the uterine cervix comprise an extremely rare histopathological entity, with less than 150 cases reported in the literature to date.

Materials and Methods A 79-year-old postmenopausal female patient was referred to our gynecological department due to a pelvic mass and vaginal bleeding. A cervical curettage was performed and the histological report revealed a malignant neoplasm with high cellularity consisting of two components; the first was a chondrosarcoma and the latter a adenocarcinoma. A diagnosis of MMMT was confirmed through immunohistochemical (IHC) staining. Neoadjuvant chemotherapy and radiotherapy were implemented, and a year later the patient underwent a radical hysterectomy and oncological pelvic lymph node dissection. She remains disease-free 12 months postoperatively.

Conclusion Primary cervical carcinosarcomas are extremely rare tumors demonstrating a bipartite profile. Preoperative diagnosis with appropriate immunochemistry testing of this rare entity is crucial to decision making.

Authors' Contributions

G.T., A.K., Z.F., A.A.S., T.N., A.D., and E.N.K. contributed to conception and design. A.K., E.N.K., and A.S. were responsible for overall supervision. A.K., M.K., A.A.S., and G.T. drafted the manuscript, which was revised by E.N.K. All authors read and approved the final manuscript.




Publication History

Received: 26 December 2021

Accepted: 31 January 2022

Article published online:
02 August 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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