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J Pediatr Infect Dis 2022; 17(06): 317-320
DOI: 10.1055/s-0042-1750314
Case Report

Neisseria Meningitidis Serogroup Z–Induced Meningitis: The First Case from Turkey

Gül Arga 
1   Division of Pediatric Infectious Diseases, Department of Pediatrics, Ankara University School of Medicine, Ankara, Turkey
,
Hatice Kübra Konca
1   Division of Pediatric Infectious Diseases, Department of Pediatrics, Ankara University School of Medicine, Ankara, Turkey
,
Ayça Nur Çelik
2   Department of Pediatrics, Ankara University School of Medicine, Ankara, Turkey
,
Edin Botan
3   Division of Pediatric Intensive Care, Department of Pediatrics, Ankara University School of Medicine, Ankara, Turkey
,
Utku Çağlayan
4   Division of Pediatric Emergency, Department of Pediatrics, Ankara University School of Medicine, Ankara, Turkey
,
Halil Özdemir
1   Division of Pediatric Infectious Diseases, Department of Pediatrics, Ankara University School of Medicine, Ankara, Turkey
,
Göksel Vatansever
4   Division of Pediatric Emergency, Department of Pediatrics, Ankara University School of Medicine, Ankara, Turkey
,
Tanıl Kendirli
3   Division of Pediatric Intensive Care, Department of Pediatrics, Ankara University School of Medicine, Ankara, Turkey
,
Ergin Çiftçi
1   Division of Pediatric Infectious Diseases, Department of Pediatrics, Ankara University School of Medicine, Ankara, Turkey
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Abstract

Neisseria meningitidis is a significant worldwide cause of bacterial meningitis and sepsis. High case-fatality rates and severe complications in survivors can occur. We present a 1-month 23-day-old case diagnosed with meningococcal meningitis and sepsis, in which serogroup Z of N. meningitidis was isolated from cerebrospinal fluid and blood cultures and treated with ceftriaxone for 7 days. Our patient is the first case of N. meningitidis serogroup Z–induced invasive meningococcal infection in Turkey. N. meningitidis serogroup Z is not included in the current meningococcal vaccines. It is concerning that a nonvaccine serogroup caused this invasive meningococcal disease and that even if the vaccine would cover this serogroup, it has happened before the usual age of administration. Therefore, meningococcal disease surveillance should continue, and an effective prevention and control strategy for nonvaccine serogroups should be implemented.

Keywords

Neisseria meningitidis - meningococcal infection - meningitis - serogroup Z


Publication History

Received: 16 February 2022

Accepted: 05 May 2022

Article published online:
11 July 2022

© 2022. Thieme. All rights reserved.

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  • References

  • 1 World Health Organization. Meningococcal meningitis. Accessed June 15, 2021. Available at: https://www.who.int/news-room/fact-sheets/detail/meningococcal-meningitis
    PubMedGoogle Scholar
  • 2 Pollard AJ, Sadarangani M. Neisseria meningitidis (meningococcus). In: Kliegman RM, Stanton BMD, St Geme J, Schor NF. eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: W. B. Saunders; 2019: 1469-1478
    Google Scholar
  • 3 Pollard AJ, Finn A. Neisseria meningitidis . In: Long SS, Prober C, Fischer M. eds. Principles and Practice of Pediatric Infectious Diseases. 5th ed. Philadelphia, PA: Elsevier 2019: 3753-3796
    Google Scholar
  • 4 Parikh SR, Campbell H, Bettinger JA. et al. The everchanging epidemiology of meningococcal disease worldwide and the potential for prevention through vaccination. J Infect 2020; 81 (04) 483-498
    CrossrefPubMedGoogle Scholar
  • 5 Aye AMM, Bai X, Borrow R. et al. Meningococcal disease surveillance in the Asia-Pacific region (2020): The global meningococcal initiative. J Infect 2020; 81 (05) 698-711
    CrossrefPubMedGoogle Scholar
  • 6 Acevedo R, Bai X, Borrow R. et al. The Global Meningococcal Initiative meeting on prevention of meningococcal disease worldwide: epidemiology, surveillance, hypervirulent strains, antibiotic resistance and high-risk populations. Expert Rev Vaccines 2019; 18 (01) 15-30
    CrossrefPubMedGoogle Scholar
  • 7 Bennett DE, Mulhall RM, Cafferkey MT. PCR-based assay for detection of Neisseria meningitidis capsular serogroups 29E, X, and Z. J Clin Microbiol 2004; 42 (04) 1764-1765
    CrossrefPubMedGoogle Scholar
  • 8 Ryan NJ, Hogan GR. Severe meningococcal disease caused by serogroups X and Z. Am J Dis Child 1980; 134 (12) 1173
    PubMedGoogle Scholar
  • 9 Trop Skaza A, Selic Kurincic T, Beskovnik L, Paragi M, Bozanic V. First case of meningococcal meningitis due to Neisseria meningitidis serogroup Z′ in Slovenia, December 2010. Euro Surveill 2011; 16 (06) 19786
    CrossrefPubMedGoogle Scholar
  • 10 Tekin RT, Dinleyici EC, Ceyhan M. et al. The prevalence, serogroup distribution and risk factors of meningococcal carriage in adolescents and young adults in Turkey. Hum Vaccin Immunother 2017; 13 (05) 1182-1189
    CrossrefPubMedGoogle Scholar
  • 11 Ceyhan M, Gürler N, Ozsurekci Y. et al. Meningitis caused by Neisseria Meningitidis, Hemophilus Influenzae Type B and Streptococcus Pneumoniae during 2005-2012 in Turkey. A multicenter prospective surveillance study. [published correction appears in Hum Vaccin Immunother. 2021 Jul 3;17(7):2351] Hum Vaccin Immunother 2014; 10 (09) 2706-2712
    CrossrefPubMedGoogle Scholar
  • 12 Ceyhan M, Ozsurekci Y, Tanır Basaranoglu S. et al. Multicenter hospital-based prospective surveillance study of bacterial agents causing meningitis and seroprevalence of different serogroups of Neisseria meningitidis, Haemophilus influenzae Type b, and Streptococcus pneumoniae during 2015 to 2018 in Turkey. MSphere 2020; 5 (02) e00060-e20
    CrossrefPubMedGoogle Scholar
  • 13 Bai X, Borrow R, Bukovski S. et al. Prevention and control of meningococcal disease: updates from the Global Meningococcal Initiative in Eastern Europe. J Infect 2019; 79 (06) 528-541
    CrossrefPubMedGoogle Scholar
  • 14 Ministry of Health Republic of Turkey. Aşı Portalı. Accessed March 31, 2022 at: https://asi.saglik.gov.tr/asi-takvimi2
    PubMedGoogle Scholar