CC BY 4.0 · Journal of Child Science 2022; 12(01): e79-e82
DOI: 10.1055/s-0042-1751269
Case Report

Acute Hepatitis C Virus Infection Treated with Daclatasvir/Sofosbuvir in a 9-Year-Old Boy

1   Pediatric Gastroenterology and Hepatology Research Center, Pediatric Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
,
Fatemeh Farahmand
2   Department of Pediatric Gastroenterology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
,
Ghobad Heidari
3   Department of Pediatric, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
› Author Affiliations

Abstract

The present study includes a case report of a 9-year-old boy who came to our center with jaundice, elevated liver enzymes, and palpable liver. He was treated with ursodeoxycholic acid, but no improvement in symptoms was seen. Reverse transcription polymerase chain reaction and liver biopsy were positive for hepatitis C virus. He was treated with daclatasvir/sofosbuvir for 3 months. Daclatasvir/sofosbuvir might be effective against the treatment of hepatitis in children, with no report of remission and minimal side effects.

Note

Consent was not obtained to publish the case report. This report does not contain any personal information that could lead to the identification of the patient.


Availability of Data and Material

Data sharing is not applicable to this article as no data sets were generated or analyzed during the current study.




Publication History

Received: 21 October 2021

Accepted: 08 May 2022

Article published online:
15 September 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • References

  • 1 Squires JE, Balistreri WF. Hepatitis C virus infection in children and adolescents. Hepatol Commun 2017; 1 (02) 87-98
  • 2 Mahmud S, Akbarzadeh V, Abu-Raddad LJ. The epidemiology of hepatitis C virus in Iran: systematic review and meta-analyses. Sci Rep 2018; 8 (01) 150
  • 3 Lohia P, Jinjuvadia R, May E. Profound jaundice in a patient with acute hepatitis C. BMJ Case Rep 2013; 2013: bcr2013200233
  • 4 Li DK, Chung RT. Overview of direct-acting antiviral drugs and drug resistance of hepatitis C virus. Methods Mol Biol 2019; 1911: 3-32
  • 5 Lagging M, Wejstål R, Norkrans G. et al; Swedish Consensus Group. Treatment of hepatitis C virus infection for adults and children: updated Swedish consensus recommendations. Infect Dis (Lond) 2016; 48 (04) 251-261
  • 6 Maughan A, Ogbuagu O. Pegylated interferon alpha 2a for the treatment of hepatitis C virus infection. Expert Opin Drug Metab Toxicol 2018; 14 (02) 219-227
  • 7 Merat S. et al. The efficacy of 12 weeks of sofosbuvir, daclatasvir, and ribavirin in treating hepatitis C patients with cirrhosis, genotypes 1 and 3. Hepat Mon 2017; 17 (01) e44564
  • 8 Agha RA, Franchi T, Sohrabi C, Mathew G, Kerwan A. SCARE Group. The SCARE 2020 guideline: updating consensus Surgical CAse REport (SCARE) guidelines. Int J Surg 2020; 84: 226-230
  • 9 Collins LF, Chan A, Zheng J. et al. Direct-acting antivirals improve access to care and cure for patients with HIV and chronic HCV infection. Open Forum Infect Dis 2017; 5 (01) ofx264-ofx264
  • 10 Li C, Hu J. A case report of sofosbuvir and daclatasvirto treat a patient with acute hepatitis C virus genotype 2 monoinfection. Medicine (Baltimore) 2018; 97 (15) e0416
  • 11 Rockstroh JK, Bhagani S, Hyland RH. et al. Ledipasvir-sofosbuvir for 6 weeks to treat acute hepatitis C virus genotype 1 or 4 infection in patients with HIV coinfection: an open-label, single-arm trial. Lancet Gastroenterol Hepatol 2017; 2 (05) 347-353
  • 12 Welzel TM, Petersen J, Herzer K. et al. Daclatasvir plus sofosbuvir, with or without ribavirin, achieved high sustained virological response rates in patients with HCV infection and advanced liver disease in a real-world cohort. Gut 2016; 65 (11) 1861-1870
  • 13 Abdel Ghaffar TY, El Naghi S, Abdel Gawad M. et al. Safety and efficacy of combined sofosbuvir/daclatasvir treatment of children and adolescents with chronic hepatitis C genotype 4. J Viral Hepat 2019; 26 (02) 263-270
  • 14 Yakoot M, El-Shabrawi MH, AbdElgawad MM. et al. Dual sofosbuvir/daclatasvir therapy in adolescent patients with chronic hepatitis C infection. J Pediatr Gastroenterol Nutr 2018; 67 (01) 86-89
  • 15 El-Shabrawi MH, Abdo AM, El-Khayat HR, Yakoot M. Shortened 8 weeks course of dual sofosbuvir/daclatasvir therapy in adolescent patients, with chronic hepatitis C infection. J Pediatr Gastroenterol Nutr 2018; 66 (03) 425-427