CC BY 4.0 · SynOpen 2022; 06(04): 258-262
DOI: 10.1055/s-0042-1751375
paper

A Practical and Economical Route to (S)-Glycidyl Pivalate

a   Medicines for All Institute, 737 N. 5th St., Box 980100, Richmond VA, 23298-0100, USA
,
Le Chang
b   WuXi AppTec (Wuhan) Co. Ltd., Wuhan East Lake High-tech Development Zone, Wuhan 430075, P. R. of China
,
Dan Chen
b   WuXi AppTec (Wuhan) Co. Ltd., Wuhan East Lake High-tech Development Zone, Wuhan 430075, P. R. of China
,
Binglin Wang
b   WuXi AppTec (Wuhan) Co. Ltd., Wuhan East Lake High-tech Development Zone, Wuhan 430075, P. R. of China
,
Raymond N. Dominey
c   Department of Chemistry, Gottwald Center for the Sciences, University of Richmond, VA 23173, USA
,
Daniel W. Cook
a   Medicines for All Institute, 737 N. 5th St., Box 980100, Richmond VA, 23298-0100, USA
,
Justina M. Burns
a   Medicines for All Institute, 737 N. 5th St., Box 980100, Richmond VA, 23298-0100, USA
,
Rodger W. Stringham
a   Medicines for All Institute, 737 N. 5th St., Box 980100, Richmond VA, 23298-0100, USA
,
a   Medicines for All Institute, 737 N. 5th St., Box 980100, Richmond VA, 23298-0100, USA
,
a   Medicines for All Institute, 737 N. 5th St., Box 980100, Richmond VA, 23298-0100, USA
› Author Affiliations
We thank the Bill and Melinda Gates Foundation for continuous support of our research.


Abstract

An efficient method to prepare enantiopure (S)-glycidyl pivalate from (R)-epichlorohydrin and pivalic acid is reported. This work provides an alternative to the synthesis of this important building block from readily available and inexpensive materials.

Supporting Information



Publication History

Received: 25 August 2022

Accepted after revision: 15 September 2022

Article published online:
19 October 2022

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