Decompressive Craniectomy in Pediatric Traumatic Brain Injury: A Retrospective Cohort Study

Abstract

Decompressive craniectomy (DC) in children with traumatic brain injury (TBI) and refractory raised intracranial pressure (ICP) remains controversial. We aimed to describe the clinical and operative characteristics of children with moderate to severe TBI who underwent DC, and compare outcomes with those who had medical therapy. We performed a retrospective observational cohort study on children < 16 years of age with moderate to severe TBI (Glasgow coma scale [GCS] ≤13) who underwent DC in two pediatric centers in Singapore and China between 2014 and 2017, and compared their outcomes with children who underwent medical treatment, among participating centers of the Pediatric Acute and Critical Care Medicine Asian Network. We defined poor functional outcomes as moderate, severe disability, vegetative or comatose state, or mortality, using the Pediatric Cerebral Performance Category scale. We performed multivariable logistic regression to identify predictors for poor functional outcomes. We analyzed 18 children who underwent DC with 214 who had medical therapy. A greater proportion of children with DC (14, 77.8%) experienced poor functional outcomes, compared with those with medical therapy (87, 41.2%, p = 0.003). Children who underwent DC had fewer median 14-day intensive care unit (ICU)-free days (2.5 days, interquartile range [IQR]: 0.0–5.8 vs. 8.0 days, IQR: 0.0–11.0, p = 0.033), median 28-day hospital-free days (0 day, IQR: 0.0–3.5 vs. 11.0 days, IQR: 0.0–21.0, p = 0.002) and 14-day mechanical ventilation-free days (6.5 days, IQR: 0.0–12.3 vs. 11.0 days, IQR: 3.0–14.0, p = 0.011). After accounting for age, sex, GCS, cerebral edema, uncal herniation, nonaccidental injury, and need for intubation, there was no significant association between DC and poor functional outcomes (adjusted odds ratio: 1.59, 95% confidence interval: 0.35–7.24, p = 0.548). Children with DC had severe injuries, and prolonged hospital and ICU stays. Future studies are needed to understand the effectiveness of DC on children with TBI.

Keywords

pediatric - head injury - traumatic brain injury - decompressive craniectomy - raised intracranial pressure

Data Availability

Due to the nature of this research, participants of this study did not agree for their data to be shared publicly, so supporting data are not available.

Authors' Contribution

All authors were involved in study conception and design. Data collection was performed by S.L.C., H.X.D., and D.S.D. Statistical analysis was performed by W.X.Y.. J.H.L. and S.Y.Y.L. were involved in data interpretation. W.X.Y. and S.L.C. drafted the initial manuscript. All authors were involved in the critical review and revision of the manuscript.

Publikationsverlauf

Eingereicht: 12. April 2022

Angenommen: 05. Januar 2023

Artikel online veröffentlicht:
10. Februar 2023

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