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CC BY-NC-ND 4.0 · J Pediatr Infect Dis 2024; 19(05): 287-293
DOI: 10.1055/s-0044-1788678
Original Article

Clinical and Biochemical Features of Kids with COVID-19 Febrile Seizures during the Omicron Wave

Authors

  • Yu Shi

    1   Department of Medical Affairs, National Children's Medical Center Children's Hospital of Fudan University, Shanghai, China

  • Shijian Miao

    2   Department of Gastroenterology, National Children's Medical Center Children's Hospital of Fudan University, Shanghai, China

  • Guomei Shen

    3   Outpatient and Emergency Management Office, National Children's Medical Center Children's Hospital of Fudan University, Shanghai, China

  • Jin Fu

    1   Department of Medical Affairs, National Children's Medical Center Children's Hospital of Fudan University, Shanghai, China

  • Xuan Gao

    3   Outpatient and Emergency Management Office, National Children's Medical Center Children's Hospital of Fudan University, Shanghai, China

  • Xiaonan Du

    4   Department of Neurology, National Children's Medical Center Children's Hospital of Fudan University, Shanghai, China

  • Guoying Huang

    5   Heart Canter, National Children's Medical Center Children's Hospital of Fudan University, Shanghai, China

  • Shuizhen Zhou

    4   Department of Neurology, National Children's Medical Center Children's Hospital of Fudan University, Shanghai, China

  • Xiaowen Zhai

    6   Department of Hematology, National Children's Medical Center Children's Hospital of Fudan University, Shanghai, China

Funding This work was supported by the Shanghai Hospital Association (202150028) and the Shanghai Hospital Development Center (2022SKMR-17).
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Abstract

Objective Mild symptoms are the norm for children with coronavirus disease-2019 (COVID-19), but data on the Omicron form are few. One of the most frequent neurological symptoms of COVID-19 in children is febrile seizure (FS).

Methods Patients with FS who visited the pediatric fever clinic between December 6 and December 31, 2022, when the Omicron version of SARS-CoV-2 was the predominant strain, were included in this retrospective, single-center analysis.

Results Children who tested positive for COVID-19 had a 5.58% incidence of FSs. Compared to patients without COVID-19, a greater percentage of COVID-19 patients (29.5 vs. 7.5%, p < 0.01) experienced complex FSs. In the COVID-19-positive group, four cases were critically unwell and were admitted to the Intensive Care Unit (1.4 vs. 0%, p < 0.01), and the admission proportion was greater (18.9 vs. 1.9%, p < 0.01). The proportion of lactic acid and IL-6 increase was larger in the COVID-19-positive group (33.5 vs. 21.5%, 22.1 vs. 17.8%, p = 0.022, p = 0.006, respectively).

Conclusion Infections with COVID-19 in children have been linked to FSs in the Omicron era. To fully understand the neuropathogenesis of seizures in children with COVID-19, more research is required.

Keywords

febrile seizures - COVID-19 - Omicron - pandemic - convulsions

Author's Contributions

Y.S., S.M., and X.Z. designed the study, participated in its implementation, analyzed, and wrote the initial draft of the manuscript. G.S., J.F., X.G., and X.D. collected the data and carried out the initial analyses. G.H., X.Z., and S.Z. reviewed the study results. X.Z. and S.Z. conceptualized and designed the study, coordinated and supervised data collection, and critically reviewed the manuscript. All authors approved the final manuscript and agreed to be responsible for all aspects of the work.




Publikationsverlauf

Eingereicht: 11. Januar 2024

Angenommen: 09. Juli 2024

Artikel online veröffentlicht:
01. August 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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