Enterobacter cloacae as a Rare Cause of Cerebral Abscesses in a Neonatal Late-Onset Sepsis—a Case Report and Literature Review with Focus on Risk Factors, Diagnostics, and Treatment

Abstract

Late-onset sepsis (LOS; sepsis occurring after the first 72 h of life) increases the morbidity and mortality of premature neonates, especially those with very low birth weight (≤1,500 g). In LOS, Enterobacter cloacae has been rarely described as a cause of secondary brain abscesses. Our case report summarizes important aspects of cerebral abscesses due to an E. cloacae sepsis in a preterm neonate. Our patient received surgical abscess drainage and rational antibiotic treatment, employing prolonged meropenem infusions plus fosfomycin and subsequent treatment with oral trimethoprim/sulfamethoxazole. Furthermore, we present a review of the current literature from 2009 to 2022, comparing cases similar to our case.

Keywords

cerebral abscesses - Enterobacter cloacae - neonatal sepsis - late-onset sepsis - antimicrobial resistance

Publikationsverlauf

Eingereicht: 13. Januar 2024

Angenommen: 11. Oktober 2024

Artikel online veröffentlicht:
19. November 2024

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