Aktuelle Ernährungsmedizin 2025; 50(02): e4-e5
DOI: 10.1055/s-0045-1809089
Abstracts
POSTERS

Dietary Eicosapentaenoic Acid (EPA) and Arachidic Acid as Predictors of Positive Therapy Response in Multiple Myeloma Patients

A Gambihler
1   Department of Hematology and Oncology, Heidelberg University Hospital
,
L Sester
1   Department of Hematology and Oncology, Heidelberg University Hospital
,
G Poschet
2   Metabolomics Core Technology Platform, Centre for Organismal Studies (COS), Heidelberg University, Heidelberg
,
C K Stein-Thoeringer
3   Department of Internal Medicine I and M3 Research Institute, University Clinic Tuebingen, Tuebingen, Germany
,
M-S Raab
1   Department of Hematology and Oncology, Heidelberg University Hospital
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Introduction: Multiple myeloma (MM) is a hematologic malignancy characterized by plasma cell infiltration of the bone marrow. Nutritional factors, particularly anti-inflammatory fatty acids, may influence disease progression and therapy outcomes.

Objectives: Eicosapentaenoic acid (EPA) and arachidic acid are long-chain fatty acids with potential therapeutic benefits. However, their role, along with short-chain fatty acids (SCFAs), polyunsaturated fatty acids (PUFAs), and oleic acid, in predicting treatment response remains unclear.

Methods: This study evaluates the association between fatty acid intake and therapy response in 62 MM patients by diet tracking and serum metabolomics analysis in 21 patients using the MxP Quant 500 XL kit. Bayesian logistic regression, Spearman, and Pearson correlations assessed factors associated with complete remission (CR), therapy outcomes CR or very good partial response (VGPR) and plasma cell infiltration.

Results: EPA intake positively predicted CR (β=29.08, p=0.037) after induction therapy. Arachidic acid was significantly linked to achieving CR or VGPR after stem cell transplantation (β=28.43, p=0.0117). Plasma cell infiltration correlated with omega-3 fatty acids (r=-0.293, p<0.001), PUFAs (r=-0.418, p<0.001), SCFAs (r=-0.324, p<0.001), and oleic acid (r=-0.365, p<0.001) from dietary sources. Metabolomics data showed similar correlations for propionic acid (r=-0.367, p<0.001) and isovaleric acid (r=-0.397, p<0.001).

[Figure 1]: a) Higher dietary EPA intake in patients with CR. b) Increased arachidic acid intake linked to better therapeutic response. c) Negative correlations between histologic plasma cell infiltration and dietary/metabolomics variables (*p<0.05). d) Negative correlations shown by regression lines.

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Fig. 1  

Conclusion: These findings suggest dietary EPA and arachidic acid, along with endogenous fatty acid metabolism, may modulate plasma cell activity and enhance therapy response. This highlights the potential for dietary interventions as adjunctive strategies in MM management. Further studies with larger cohorts are needed to support these findings [1].



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Artikel online veröffentlicht:
25. Mai 2025

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  • References

  • 1 Shah UA, Maclachlan KH, Derkach A. et al. Sustained Minimal Residual Disease Negativity in Multiple Myeloma is Associated with Stool Butyrate and Healthier Plant-Based Diets. Clin Cancer Res 2022; 28: 5149-5155
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