Total Synthesis of Galtamycinone, the Common Aglycon of the C-Glycosyl Naphthacenequinone Antibiotics
31 December 2000 (online)
Total synthesis of galtamycinone (1), the common structure in the C-glycosyl naphthacenequinone-class antibiotics, is described. The key step is the base-promoted regioselective cycloaddition of C-glycosyl chloronaphthoquinone 2 with homophthalic anhydride 6.
Total synthesis - Naphthacenequinone - Antibiotic - Aryl C-glycoside - Cycloaddition