Am J Perinatol 1999; Volume 16(Number 8): 0403-0406
DOI: 10.1055/s-1999-6819
Copyright © 1999 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel: +1(212)760-0888 x132

Successful Outcome After Antibiotic Treatment of Postamniocentesis Membrane Rupture and Chorioamnionitis in Multiple Pregnancy

Alessandro Ghidini, Valentina Doria, Valentina Kirn, Victoria Korker
  • Perinatal Diagnostic Center, Inova Alexandria Hospital, Alexandria, Virginia
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31. Dezember 1999 (online)


-Postamniocentesis chorioamnionitis is usually managed with induction of labor to prevent maternal sepsis and related morbidity and mortality. We report a case of chorioamnionitis in a triplet pregnancy after midtrimester genetic amniocentesis, in which multiple antibiotic treatment (ampicillin 2 g i.v. loading dose followed by 1 g i.v. every 6 hr; clindamycin 900 mg i.v. every 8 hr; gentamicin 120 mg i.v. loading dose followed by 100 mg i.v. every 8 hrs; and erythromycin 500 mg i.v. every 6 hr) for 7 days and delivery of the presumably infected triplet A successfully reversed the clinical symptomatology, allowing prolongation of pregnancy until 26 weeks and survival of the remaining fetuses. At age 2 years, both infants are doing well and are meeting their developmental milestones. The viable outcome of this management strategy suggests that antibiotic treatment and expectancy may be an option in selected cases of postamniocentesis chorioamnionitis in multiple pregnancies.