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Endoscopy 2000; 32(12): 994-997
DOI: 10.1055/s-2000-9616
Case Report
© Georg Thieme Verlag Stuttgart · New York

Gastric Cancer Presenting with Extremely Rapid Growth: Unprecedented Morphologic Change in a Short Time and Endoscopic Estimation of its Doubling Time

T.  Nakajima 1, 2 , H.  Konishi 1, 2 , Y.  Tatsumi 1, 2 , Y.  Sakamoto 1, 2 , Y.  Yamane 1, 2 , S.  Misawa 1, 2 , S.  Toyama 1, 2 , T.  Ochiai 3 , K.  Kashima 2 , E.  Konishi 4 , Y.  Tsuchihashi 4
  • 1 Department of Gastroenterology, Kyoto Prefectural Yosano-umi Hospital, Kyoto, Japan
  • 2 Department of Surgery, Kyoto Prefectural Yosano-umi Hospital, Kyoto, Japan
  • 3 Third Department of Internal Medicine, Kyoto Prefectural Yosano-umi Hospital, Kyoto, Japan
  • 4 Hospital Department of Pathology, Kyoto Prefectural University of Medicine, Kyoto, Japan
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Publication History

Publication Date:
31 December 2000 (online)

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We encountered a case of gastric cancer that was initially detected as a deep hemorrhagic ulcer without surrounding irregular elevation, followed by rapid protrusion in less than 1 month. Using endoscopic images in the follow-up study, we estimated the doubling time (DT) of this unusual tumor as 9.2 days. Since the doubling time of gastric cancer is generally fairly long due to exfoliation of many cancer cells into the gastric lumen, this cancer presented with extremely rapid growth. Besides, this case reinforces that follow-up study is important in terms of clinical management of ulcerative lesions.

References

  • 1 Collins V P, Loeffler R K, Tivey H. Observation in growth rates of human tumors.  Am J Roentgenol. 1956;  76 988-1000
    PubMedGoogle Scholar
  • 2 Fabrikant J I. The kinetics of cellular proliferation and in normal and malignant tissues; a review of methodology and the analysis of cell proliferation kinetics in human tissues.  Am J Roentgenol. 1971;  111 700
    PubMedGoogle Scholar
  • 3 Shimizu S, Tada M, Kawai K. Early gastric cancer: its surveillance and natural course.  Endoscopy. 1995;  27 27-31
    Article in Thieme ConnectPubMedGoogle Scholar
  • 4 Kohli Y, Kawai K, Fujita S. Analytical studies on growth of human gastric cancer.  J Clin Gastroenterol. 1981;  3 129-133
    CrossrefPubMedGoogle Scholar
  • 5 Cattoretti G, Becker M HG, Key G, Duchrow M, Schlutter C, Galle J, et al. Monoclonal antibodies against recombinant parts of the Ki- 67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed, paraffin-embedded tissue sections.  J Pathol. 1992;  168 357-363
    PubMedGoogle Scholar
  • 6 Gerdes J, Lemke H, Baisch H, Wacker H H, Schwab U, Stein H. Cell cycle analysis of a cell proliferation associated human nuclear antigen defined by the monoclonal antibody Ki67.  J Immunol. 1984;  133 1710-1718
    PubMedGoogle Scholar
  • 7 Gavrieli Y, Sherman Y, Ben-Sasson S A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.  J Cell Biol. 1992;  119 493-501
    CrossrefPubMedGoogle Scholar
  • 8 Pounder R E, Fraser A G. Peptic ulcer disease: medical management. In: Haubrich WS, Schaffner F, Berk JE (eds). Bockus' Gastroenterology. 5th ed.  Philadelphia; WB Saunders Co., 1995: 769
    Google Scholar
  • 9 Bernstein C N, Pettigrew N, Wang K K, Greenberg H, Lipschitz J. Multifocal gastric neoplasia after recurrent laser therapy for the watermelon stomach.  Can J Gastroenterol. 1997;  11 403-406
    PubMedGoogle Scholar

Tomoki  Nakajima, M.D.

Department of Gastroenterology Kyoto Prefectural Yosano-umi Hospital

Otokoyama Iwataki-cho

Yosa-gun

Kyoto Prefecture 629- 2261 Japan

Fax: Fax:+ 81-772-46-2728

Email: E-mail:tomnaka@silver.ocn.ne.jp

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