Conventional interval dosing (CID) and extended interval dosing (EID) of gentamicin
were compared in preterm infants. Gentamicin peak and trough levels, serum creatinine,
urine output, and hearing screens were obtained in 40 preterm infants. Results suggest
that EID is safe, provides gentamicin levels in desirable ranges (peak, 5 to 12 μg/mL;
trough <2 μg/mL), and reduces dosage adjustments.
KEYWORDS
Gentamicin - dosing interval - preterm
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Hallam HurtM.D.
Children's Hospital of Philadelphia, Division of Neonatology
34th Street and Civic Center Blvd
Philadelphia, PA 19104
